Früher|Nächster

Risk Assessment of the Onset of Sleep-related Painful Erection

  • role： First author第一作者
  • Affiliation：

    Department of Urology， Dongguan Tungwah Hospital， Dongguan 523000， China

  • Email：286619685@qq.com
  • Introduction：胡海兵，第一作者，主任医师，研究方向：阴茎异常勃起，E-mail：286619685@qq.com
HU Haibing1,  
  • Affiliation：

    Department of Urology， Dongguan Tungwah Hospital， Dongguan 523000， China

ZHAO Kunkun1,  
  • role： Corresponding author通信作者
  • Affiliation：

    Department of Urology， Dongguan Tungwah Hospital， Dongguan 523000， China

  • Email：1007492679@qq.com
  • Introduction：CHEN Yongyi； E-mail：1007492679@qq.com
CHEN Yongyi1*,  
  • Affiliation：

    Department of Urology， Dongguan People's Hospital of Southern Medical Hospital， Dongguan523059， China

LUO Daosheng2,  
  • Affiliation：

    Department of Urology， People's Hospital of Peking University， Beijing 100105， China

BAI Wenjun3,  
  • Affiliation：

    Department of Urology， Foresea Life Insurance Guangzhou General Hospital， Guangzhou 513000， China

LI Ping4,  
  • Affiliation：

    Department of Respiratory Diseases， Dongguan Tungwah Hospital， Dongguan 523000， China

ZHANG Li5

Resümee

ObjectiveSleep-related painful erections （SRPE） is a rare sleep disorder characterized by repeated awakening due to painful interruptions of penile erections during nighttime sleep， and its etiology is currently unclear. The purpose of this study is to explore the impact of potential risk factors on the incidence of SRPE.MethodsInformation was collected through questionnaires administered to patients who presented at the urology department and suffered from SRPE or did not suffer from SRPE. A total of 290 participants completed the study， including 145 controls and 145 cases. Logistic regression analysis was used to assess the impact of age， occupation， sleep initiation time per night， frequency of sexual intercourse per week， psychological status， erectile dysfunction， chronic prostatitis， prostate enlargement， lumbar spine disease， central nervous system disease， hypertension， diabetes and family history on the onset of SRPE.ResultsSingle-factor logistic regression analysis found that a history of chronic prostatitis， intellectual labor occupation， central nervous system disease， late sleep onset， frequency of sexual activity， and anxiety status might be related to the onset of SRPE. After incorporating these factors into a multivariate regression analysis model， it was found that having sexual activity ≥2 times/week （OR 95%CI = 0.326（0.179，0.592） and late sleep onset （after 24：00） （OR 95%CI = 0.494（0.265，0.918）might be protective factors for SRPE， while a history of chronic prostatitis（OR 95%CI = 3.779（2.082，6.859） might be a risk factor for SRPE. However， there was no significant statistical difference in the impact of central nervous system diseases and occupation on multivariate analysis.ConclusionChronic prostatitis and anxiety status may be independent risk factors for SRPE； having sexual activity ≥2 times/week and delaying sleep time appropriately may be independent protective factors.

Schlüsselwort

Sleep;abnormal erection;painful erection;erectile dysfunction： risk assessment

References

  1. 1.
    Burnett AL. Rare disorders of penile erection［J］. Fertil Steril， 2020， 113（1）： 6-12.
  2. 2.
    Hu HB， Chen YL， Guang X， et al. Diagnosis and treatment strategies for sleep-related painful erection （with 9 case reports） ［J］. Natl J Androl， 2016， 22（4）： 330-334.
  3. 3.
    Sateia MJ. International classification of sleep disorders - third edition： highlights and modifications［J］. Chest， 2014， 146（5）： 1387-1394.
  4. 4.
    Sun YH. Wu Jieping's Urology［M］. Peoples Medical Publishing House ， 2019，2002-2004.
  5. 5.
    Karsenty G， Werth E， Knapp PA， et al. Sleep-related painful erections［J］. Nat Clin Pract Urol， 2005， 2（5）： 256-260.
  6. 6.
    Salonia A， Eardley I， Giuliano F， et al. European Association of Urology guidelines on priapism［J］. Eur Urol， 2014， 65（2）： 480-489.
  7. 7.
    Vreugdenhil S， Weidenaar AC， De Jong IJ， et al. Sleep-related painful erections - a case series of 24 patients regarding diagnostics and treatment options［J］. Sex Med， 2017， 5（4）： e237-e243.
  8. 8.
    Barnhoorn PC， Gianotten WL， Van Driel MF. Sleep-related painful erections following sexual intercourse［J］. Arch Sex Behav， 2018， 47（3）： 815-817.
  9. 9.
    Ferre A， Vila J， Jurado MJ， et al. Sleep-related painful erections associated with obstructive sleep apnea syndrome［J］. Arch Sex Behav， 2012， 41（4）： 1059-1063.
  10. 10.
    Vreugdenhil S， Weidenaar AC， De Jong IJ， et al. Sleep-related painful erections： a meta-analysis on the pathophysiology and risks and benefits of medical treatments［J］. The Journal of Sexual Medicine， 2018， 15（1）： 5-19.
  11. 11.
    Hu HB， Zhao KK， Li P， et al. Research progress on sleep related painful erections ［J］. Natl Med J China， 2020， 100（8）：638-640.
  12. 12.
    De Rose AF， Giglio M， De Caro G， et al. Arterial priapism and cycling： a new worrisome reality？［J］. Urology， 2001， 58（3）： 462.
  13. 13.
    Golash A， Gray R， Ruttley MS， et al. Traumatic priapism： an unusual cycling injury［J］. Br J Sports Med， 2000， 34（4）： 310-311.
  14. 14.
    Gravel J， Leblanc C， Varner C. Management of priapism with a trial of exercise in the emergency department［J］. CJEM， 2019， 21（1）： 150-153.
  15. 15.
    Calvert JW， Lefer DJ. Role of beta-adrenergic receptors and nitric oxide signaling in exercise-mediated cardioprotection［J］. Physiology （Bethesda）， 2013， 28（4）： 216-224.
  16. 16.
    Prieto D. Physiological regulation of penile arteries and veins［J］. Int J Impot Res， 2008， 20（1）： 17-29.
  17. 17.
    Forstermann U， Sessa WC. Nitric oxide synthases： regulation and function［J］. Eur Heart J， 2012， 33（7）： 829-837.
  18. 18.
    Allen MS， Walter EE. Health-related lifestyle factors and sexual dysfunction： a meta-analysis of population-based research［J］. Sex Med， 2018， 15（4）： 458-475.
  19. 19.
    Chung SD， Huang CC， Lin HC. Chronic prostatitis and depressive disorder： a three year population-based study［J］. J Affect Disord， 2011， 134（1-3）： 404-409.
  20. 20.
    Wang CS， Kao WT， Chen CD， et al. Priapism associated with typical and atypical antipsychotic medications［J］. Int Clin Psychopharmacol， 2006， 21（4）： 245-248.
  21. 21.
    Meltzer HY. Update on typical and atypical antipsychotic drugs［J］. Annu Rev Med， 2013， 64（1）： 393-406.
  22. 22.
    Schifano N， Capogrosso P， Boeri L， et al. Medications mostly associated with priapism events： Assessment of the 2015-2020 Food and Drug Administration （FDA） pharmacovigilance database entries［J］. Int J Impot Res， 2022.21（5）：583-590.
  23. 23.
    Bhat IA， Shannon KD， Ara A， et al. Ninety-six hours ordeal of priapism induced by paroxetine--a case report and literature review［J］. Int J Psychiatry Med， 2015， 50（3）： 326-334.
  24. 24.
    Unal S， Micoogullari U， Okulu E， et al. Priapism - a rare side effect of alpha blockers： Report of 2 cases and literature review［J］. Rev Int Androl， 2022， 20（3）： 211-216.
  25. 25.
    Marconi M， Pavez P， San Francisco I， et al. Priapism induced by use of tamsulosin： a case report and review of the literature［J］. Arch Ital Urol Androl， 2019， 91（3）.194-195.
  26. 26.
    Russom M， Fitsum Y， Debesai M， et al. Tamsulosin and risk of priapism： a causality assessment using Austin Bradford Hill Criteria［J］. Pharmacol Res Perspect， 2022， 10（2）： 01-09.
  27. 27.
    Duan CQ， Zhang K， Shao LQ. Doxazosin and hypererectile dysfunction （with reports of 10 cases）［J］. Chinese Journal of Andrology， 2011， 25（12）： 012-017.
  28. 28.
    Zhou SH， Li X， Guo YF， et al. Sleep disorders related headache［J］. Apo & Ner Dis，2023， 40（3）：238-240.
  29. 29.
    Hu HB ， Zhao KK ， Chen YY，et al. Difference in nocturnal erectile function between SRPE patients and normal people［J］. J Sun Yat-sen Univ （Med Sci）， 2023， 44（4）： 691-696.
  30. 30.
    Balercia G， Boscaro M， Lombardo F， et al. Sexual symptoms in endocrine diseases： psychosomatic perspectives［J］. Psychother Psychosom， 2007， 76（3）： 134-140.
  31. 31.
    Lefter R， Cojocariu RO， Ciobica A， et al. Interactions between sleep and emotions in humans and animal models［J］. Medicina （Kaunas）， 2022， 58（2）：1-17.
  32. 32.
    Li MT， Robinson CL， Ruan QZ， et al. The influence of sleep disturbance on chronic pain［J］. Curr Pain Headache Rep， 2022， 26（10）： 795-804.
  33. 33.
    Goldstein AN， Walker MP. The role of sleep in emotional brain function［J］. Annu Rev Clin Psychol， 2014， 10： 679-708.
  34. 34.
    Lu Y， Zhang J， Su H， et al. Improvement of associated symptoms using combined therapy in 44 patients with sleep-related painful erection during 1-year follow up［J］. Andrologia， 2022， 54（8）： 1472-1480.
  35. 35.
    Luppi PH， Clement O， Fort P. Paradoxical （REM） sleep genesis by the brainstem is under hypothalamic control［J］. Curr Opin Neurobiol， 2013， 23（5）： 786-792.
  36. 36.
    Jennum P， Christensen JA， Zoetmulder M. Neurophysiological basis of rapid eye movement sleep behavior disorder： informing future drug development［J］. Nat Sci Sleep， 2016， 8： 107-120.
  37. 37.
    Szucs A， Janszky J， Barsi P， et al. Sleep-related painful erection is associated with neurovascular compression of basal forebrain［J］. J Neurol， 2002， 249（4）： 486-487.
  38. 38.
    Johnson MJ， Mcneillis V， Chiriaco G， et al. Rare disorders of painful erection： a cohort study of the investigation and management of stuttering priapism and sleep-related painful erection［J］. Sex Med.2021， 18（2）： 376-384.
  39. 39.
    Johnson M， Mcneillis V， Gutbier J， et al. Differences in polysomnographic， nocturnal penile tumescence and penile doppler ultrasound findings in men with stuttering priapism and sleep-related painful erections［J］. Int J Impot Res， 2022， 34（6）： 603-609.
  40. 40.
    Dai AJ， Li M， Wang LL， et al. Improvement of erection related incision pain in circumcision patients using interrupted rapid eye movement sleep： a randomized controlled study［J］. Urol J， 2018， 15（3）： 126-131.
  41. 41.
    Campbell IG， Cruz-Basilio A， Darchia N， et al. Effects of sleep restriction on the sleep electroencephalogram of adolescents［J］. Sleep， 2021， 44（6）：1-9.
  42. 42.
    Maric A， Lustenberger C， Werth E， et al. Intraindividual Increase of homeostatic sleep pressure across acute and chronic sleep loss： a high-density EEG study［J］. Sleep， 2017， 40（9）：11-18.
  43. 43.
    Myers C， Smith M. Pelvic floor muscle training improves erectile dysfunction and premature ejaculation： a systematic review［J］. Physiotherapy， 2019， 105（2）： 235-243.

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