【Objective】 To investigate the effects of interleukin- 17（IL- 17）on the proliferation and migration of bronchial smooth muscle cells（BSMC）and the role of JAK/STAT3 signaling pathway in this process.【Methods】BSMC were treated with different concentrations of IL- 17 for different times to determine the best of the experimental condition. Then MTT assay was used to detect cell viability. Cell proliferation states were detected by BrdU staining ，and the cell cycle was assessed by PI staining using a flow cytometer. Transwell cell migration assay was further used to detect cell migration ability. The expression of JAK ，p-JAK ，STAT3 and p-STAT3 in BSMC after being treated with IL-17 was detected by Western blotting. JAK/STAT3 signaling pathway specific blocker AG490 was used to investigate the role of JAK/STAT3 signaling pathway in IL-17-induced BSMC proliferation and migration. The effects of IL-17 on cell proliferation， migration and JAK/STAT3 signaling pathway related protein expression were evaluated after blocking the JAK/STAT3 signaling.【Results】IL-17 enhanced the proliferation（P < 0.05），promoted the cell cycle transitions（P < 0.05）and significantly increases the migration ability（P < 0.05）in BSMC. This process was accompanied by the enhancement of JAK/STAT3 signaling pathway in BSMC（P < 0.05）. Inhibition of JAK/STAT3 signaling pathway alleviated BSMC proliferation and migration induced by IL-17（P < 0.05）.【Conclusions】JAK/STAT3 signaling pathway participates in the stimulation process of IL- 17 on the proliferation and migration of BSMC. AG490 inhibits the enhancement of JAK/STAT3 signaling pathway in BSMC induced by interleukin-17.