【Objective】To analyze the effects of lung protective ventilation strategy on clinical outcome and right heart function of ARDS patients.【Methods】From January 2016 to June 2017，ICU patients fulfilling the consensus criteria for acute respiratory distress syndrome were included in the study. 52 patients，aged（48±7）years old，were randomly divided into control group（24 cases）and lung protection group（28 cases）. Control group was ventilated with a tidal vol? ume of 8~15 mL/kg standard weight，PEEP 4~8 cmH2O，plateau pressure 30~35 cmH2O，while lung protection group with a tidal volume of 6 mL/kg predicted body weight，PEEP（positive end expiratory pressure）set by PEEP-FiO2 table， plateau pressure <30 cmH2O. The values of PaO2（arterial partial pressure of oxygen），PCO2（arterial partial pressure of carbon dioxide），OI（oxygenation index），Lac（lactic acid），TAPSE（tricuspid annular plane systolic excursion），RVarea/ LVarea（right ventricular end-diastolic area/left ventricular end-diastolic area），E/A（peak mitral flow velocity of the early rapid filling wave /peak mitral flow velocity of the late rapid filling wave），E/e（peak mitral flow velocity of the early rapid filling wave/early diastolic velocity of the tricuspid annulus），PASP（pulmonary artery systolic pressure）and IVC （inferior vena cava）were collected and analyzed. 【Results】After 24 hours of ventilation，TAPSE and E/e of lung protec? tion group were higher compared to the control group，and PASP was lower compared to the control group（all P<0.05）. After 48 h of ventilation，OI，PaO2，PCO2 and Lac in the lung protective group were higher compared to the control group （all P < 0.05）；TAPSE of the lung protection group was higher compared to the control group，PASP and IVC were lower compared to the control group（all P < 0.05）. The mechanical ventilation time and hospitalization time of the lung protec? tion group were shorter compared to the control group（all P < 0.01）.【Conclusion】Compared with routine ventilation strategy，lung protective ventilation strategy shows more advantages in improving the oxygenation and reducing negative ef? fect on the right heart function of ARDS patients.