【Objective】To investigate associations between the functional polymorphisms of signal transducer and activator of transcription 4（STAT4）gene and preeclampsia.【Methods】PCR-restriction fragment length polymorphism was used to genotype rs10181656 and rs16833431 local polymorphism in 228 preeclampsia cases and 179 normal controls. 【Results】（1）The frequencies of rs10181656C/G were 35.96％，46.37％ in genotype C/C，47.81％，44.69％ in genotype C/G and 16.23％，8.94％ in genotype G/G between preeclampsia patients and normal controls. They reached statistical difference（P = 0.031）. There was different distribution in two alleles（C and G）between preeclampsia patients and normal controls（P = 0.009）.（2）There was no different distribution in 3 genotypes（C/C，C/T，T/T）and 2 alleles（C and T）of rs16833431 C/T between preeclampsia patients and normal controls（P = 0.508，0.461）.【Conclusions】Functional polymorphisms of the rs10181656 locus could associate with the preeclampsia. The polymor? phisms of the rs16833431 locus could not associate with the preeclampsia.