【Objective】To determine whether all-blastocyst-culture can benefit elderly infertile patients with low ovarian reserve. 【Methods】To retrospectively analyze elderly patients with low ovarian reserve undergoing IVF/ICSI in Reproductive Medicine Re? search Center of the Sixth Affiliated Hospital of Sun Yat-sen University from May 2016 to April 2017.We divide them into group A （All-blastocyst-culture）and group B（None-blastocyst-culture）based on different culture approach of D3 transferrable embryo. To compare the cumulative biochemical pregnancy rate，cumulative clinical pregnancy rate between them.【Results】A total of 231 eligi? ble patients are included，with130 in group A and 101 in group B. The basic conditions of the two groups show no difference. Cumula? tive biochemical pregnancy rate / clinical pregnancy rate in group A is higher than that of group B，though the difference is not statisti? cally significant（P>0.05）. After removing patients who did not undergo embryo transfer due to failure in blastocyst culture，the cumu? lative biochemical pregnancy rate/clinical pregnancy rate in group A is significantly higher than group B（P<0.05）. Multivariate analy? sis of the patient′s basic condition and the outcome of blastocyst culture showed that the number of D3 transferrable embryo was a risk factor for the failure of blastocyst culture（OR=0.277，95%CI：0.103 ~ 0.744，P<0.05）.【Conclusion】All-blastocyst-culture will not adversely affect the pregnancy outcome of elderly infertile patients with low ovarian reserve. On the contrary，once they obtain transfer? rable embryos

pregnancy outcome in All-Blastocyst-Culture group are better than None-Blastocyst-Culture group. A small number of D3 transferrable embryo is a risk factor for failure to culture blastocyst. If the patients were fully informed consent，we can consider implementing all-blastocyst-culture for elderly infertile patients with low ovarian reserve.