【Objective】To explore whether necroptosis is involved in the mechanism of lung injury induced by intestinal isch? emia-reperfusion.【Method】Thirty-two healthy male Sprague-Dawley rats were randomly assigned into 4 groups（n = 8）：sham oper? ation group（sham group），ischemia/ reperfusion group（I/R group），necroptosis inhibitor necrostatin-1 group（Nec-1 group）and solvent dimethyl sulfoxide（DMSO）group（DMSO group）. Model of intestinal I/R injury was produced by clamping the superior mes? enteric artery for 1.5 h followed by 6 h reperfusion in rats. Necrostatin-1 1.0 mg/kg was administered 30 min before occlusion in Nec- 1 group，while the equal volume of DMSO was given instead in DMSO group. The rats were sacrificed at 6 h of reperfusion and the lung tissues were removed for measurement of wet-dry ratio and microscopic examination and scored. The expression of receptor-inter? acting protein 1（RIP1）and receptor-interacting protein 3（RIP3）in lung tissues was detected using Western-blot and immunohisto? chemistry.【Result】Compared with sham group，lung morphology score and wet/dry ratio in I/R，DMSO group raised（P < 0.05）. Lung morphology score and wet/ dry ratio statistically declined in Nec-1 group compared with I/R and DMSO group（P < 0.05）， while there was no statistical difference of wet/ dry ratio between sham group and Nec-1 group（P > 0.05）. As the result of western- blot and immunohistochemistry showed，the expression of RIP1 and RIP3 was up-regulated in I/ R group and DMSO group（P < 0.05），which was inhibited by Nec-1 in Nec-1 group（P < 0.05）.【Conclusion】Necroptosis is involved in the mechanism of lung in? jury induced by intestinal ischemia-reperfusion，and Nec-1，the special inhibitor of RIP1，can reduce the injury.