【Objectives】 To analyze the etiologies of liver dysfunction in pregnancy

clinical features and the proportional changes over 10 consecutive years. 【Methods】 Retrospectively collect the clinical data of hospitalized pregnant women with liver dysfunction in the Third Affiliated Hospital of Sun Yat-sen University from year 2005 to 2014

as well as the normal pregnant. To compare the clinical differences between the two groups

and analyze the etiological composition and the proportional changes of the case group. 【Results】 There were 1241 cases collected totally

of which 859 were in third trimester of pregnancy

and 1432 in control group

of which 983 were in third trimester. The proportion of twin pregnancy was higher in the case group than the control group (P<0.05). There were no statistically significant differences in the mean age

the proportion of in vitro fertilization and embryo transfer( IVF-ET)

childbearing history between the two groups. In all cases

the main causes were hepatitis B (808 cases

65.1%)

followed by intrahepatic cholestasis during pregnancy (ICP) (228 cases

18.4%). Pregnancy with acute fatty liver (markers) was the third largest cause of pregnancy liver damage (50 cases

4.0%). HELLP syndrome had 38 cases (3.1%). Hepatic failure had a total of 65 cases of pregnancy

mainly for hepatitis B (30 cases

accounting for 46.2%

22 cases in the third trimester) and AFLP (22 cases accounting for 38.5%

21cases in the third trimester). Compared to 2005-2009 and 2010-2009 two periods

the proportion of hepatitis B declined(72.9% vs 60.5%

P < 0.05)

while the proportion of ICP increased (6.9% vs 25.2%

P < 0.05)

and unknown causes liver damage pregnancy also declined (10.4% vs 4.2%

P < 0.05). 【Conclusion】 In recent ten years

from 2005 to 2014 in our hospital

the most important cause for liver dysfunction in pregnancy is hepatitis B

but the proportion has a downward trend; While ICP

the second cause

has a rising trend. The research on the cause of liver damage during pregnancy can help clinicians for early recognition and treatment

thereby to prevent the occurrence of severe obstetric complications.