【Objective】To explore the spatial distribution pattern of liver cancer in Sihui city，Guangdong Province from 2004 to 2011，and to provide theoretical evidence for prevention and control of liver cancer.【Methods】Spatial scan statistic was applied，and analysis were conducted by using software SaTScan 9.4.4 to detect the clusters in Sihui from 2004 to 2011.Map making and results visualizing were carried out with software ArcGIS 10.2.【Results】A total of 1252 cases was reported in Sihui City，Guangdong Province from 2004 to 2011，with the incidence of liver cancer increasing from 32.67/100000 to 41.14/100000. Spatial scans results showed that highly clustered areas are mainly located in the south and southeast，which include Dasha，Longfu and Dongcheng countries in all people（LLR=6.34，P=0.019，RR=1.31）and the male（LLR=5.83，P=0.025，RR=1.33），respectively；highly clustered areas in female were include Dasha，Dongcheng，Chengzhong and other two countries（LLR=5.18，P=0.043，RR=1.41）. Lowly clustered areas in all people are mainly located in the north，which include Luoyuan，Didou and Jiangfu countries（LLR=8.66， P=0.001，RR=0.67）.【Conclusion】The incidence of primary liver cancer in Sihui was increasing over time，and spatial clustering of the cases were observed. Further study should be focused on the risk factors of liver cancer in related areas to strengthen the prevention and control of liver cancer.