Abstract：【Objective】To analyze the prognostic factors of resectable acral melanoma patients，then develop a novel prognostic model and examined its prognostic value.【Methods】The study retrospectively analyzed clinicopathological characteristics and inflam? matory markers of 232 acral melanoma patients who underwent radical surgical resection between 2000 and 2011 at the Sun Yat-sen University Cancer Center. Kaplan-Meier curves were plotted to estimate overall survival. Significantly predictive factors were identified by multivariate Cox regression analyses and a prognostic model based on these variables was constructed to predict survival. 【Results】Cox regression analysis revealed that age，lactic dehydrogenase（LDH），stage，globulin（GLB）and C-reactive protein （CRP）were independently related to survival. After computing these scores，patients were classified into three risk groups. The new prognostic model identified three categories of patients with different prognoses（P < 0.001）and significantly stratify patient prognosis in different tumor stages. The 5-year survival rate was 42.9%，25.7%，and 3.7% in groups 1，2，and 3，respectively. The AUC of new prognostic model is 0.664（95% CI：0.599-0.724）.【Conclusion】Age，LDH，stage，GLB and CRP were independently related to survival in our study population，and the prognostic model is useful to stratify patients into different risk groups and it is a useful complement to AJCC staging for Asian patients with acral melanoma.