DAI Hai-rong, ZHOU Hui, LI Qiao-fei, et al. Treatment of Recalcitrant Plantar Warts with 5-aminolevulinic Acid Photodynamic Therapy(ALA-PDT)after Preconditioning with Superpulse Carbon Dioxide Laser[J]. Journal of Sun Yat-sen University (Medical Sciences), 2018, 39(1).
DAI Hai-rong, ZHOU Hui, LI Qiao-fei, et al. Treatment of Recalcitrant Plantar Warts with 5-aminolevulinic Acid Photodynamic Therapy(ALA-PDT)after Preconditioning with Superpulse Carbon Dioxide Laser[J]. Journal of Sun Yat-sen University (Medical Sciences), 2018, 39(1).DOI:
【Objective】To investigate the efficacy and safety of ALA-PDT following CO 2 laser preconditioning for recal? citrant plantar warts.【Methods】Patients with recalcitrant plantar warts were enrolled in this study,and received ALA-PDT treatment following CO 2 laser preconditioning. Cure rate and side effects were observed.【Results】Twenty patients were en? rolled and 85%(17/20)showed complete clearance of plantar warts after one to three times of ALA-PDT. PDT treatment time was once in two patients(10%),twice in five patients(25%)while three times in 10 patients(50%). No infection or scar tissue was observed. Five(25%)patients were infected with one type of HPV,while 15(75%)patients with two or mul? tiple types of HPV. No difference was observed in complete clearance rate between patients with single or multiple HPV gen? otypes infection.【Conclusions】Superpulse carbon dioxide laser pretreatment enhanced the efficacy of ALA-PDT treatment on recalcitrant plantar warts. Further study is needed to determine the association of HPV genotype with outcome of recalci? trant plantar warts.