【Objective】To researchthe influence of endometrectomy and hysterectomy on the physiology and mentality of patients with refractory menorrhagia.【Method】This research selected 110 patients with refractory menorrhagia that accepted in our hospital from January，2015 to January，2017 as the object of study. Under the consent of patients，they were randomly divided into the endometrectomy group and hysterectomy group. Then the rate of Self-rating Anxiety Scale （SAS）and Self-rating Depression Scale（SDS），the recovery condition of colporrhagia and improvement of anemia of both groups were compared.【Result】Before treatment，the compare between both group′s rate of SAS and SDS are not statistically significant（P>0.05），after treatment，the SAS and SDS rate of endometrectomy group are respectively （45.31±3.58）and（46.31±3.46），which are both significantly lower than the hysterectomy group（P<0.05）；the endomet? rectomy group has a good rate of 94.55% on the recovery condition of colporrhagia，which is significantly higher than the hysterectomy group′s 81.81%（P<0.05）；before surgery，the compare of hemoglobin quantity between two group are not statistically significant（P>0.05）；within 1，3 and 6 months after surgery，the hemoglobin level of endometrectomy group are significantly higher than the hysterectomy group（P<0.05）.【Conclusion】Both endometrectomy and hysterectomy can effectively treat patients with refractory menorrhagia，but endometrectomy has less influence on patient′s physiology and mentality，which can facilitate patient′s recovery and could be widely applied on clinical treatment.