【Objective】Based on the resting state functional magnetic resonance imaging to investigate the abnormal features of the functional connectivity of resting brain neural network in the patients with primary insomnia，by using voxel-wise whole-brain functional networks analysis of degree centrality（DC）for imaging evidence of neural mechanisms underlying primary insomnia. 【Methods】The resting state fMRI were performed in 59 PI patients and 47 age，education，and sex- matched normal healthy subjects. Analysis of DC map changes between the two patient groups and the control group were performed by two sample t test. （threshold at P < 0.05）.【Results】Compared with the control group，the patients with PI showed significantly reduced DC value in bilateral medial frontal gyrus（MFG），bilateral anterior cingulate gyrus（ACG），and right insula；and increased DC value in right middle temporal gyrus（MTG），and left cuneus，（CUN），P < 0.05.【Conclusion】Changes of DC value occurred in some region of brain in the PI patient groups when compared with the control group. It was indicated that DC，as a novel resting-state fMRI parameter in the voxel-wise whole-brain functional networks，might be an appealing alternative approach for further study on pathologic and neuropsychological states of PI.