Metabolic rearrangement is a typical hallmark of cancer cells，especially the disorders in glucose metabolism. Normal cells rely on the steps of oxidative phosphorylation within the mitochondria to metabolize glucose and yield energy upon enough oxygen，yet turning to glycolysis in the absence of oxygen ． Nevertheless，tumor cells exhibit high levels of glycolytic flux in different environments，due to the requirement of malignant proliferation. This phenomenon was named as the Warburg effect，the initiation of which is driven by multiple mechanisms ，including the influence of tumor microenvironment ，the activa? tion of tumor-promoting signaling pathways ，and the aberrant levels of metabolic enzymes. Moreover ，our recent findings sug? gest that inhibition of gluconeogenesis ，the general reversal of glycolysis ，would further promote the Warburg effect and tumor progression.