Vascular calcification is a common pathology frequently occurred in the process of atherosclerosis，hypertension， diabetes，chronic kidney disease，vascular injury and aging，resulting in an increased prevalence of cardiovascular events. Along with the social aging process，the incidence becomeshigher，andthis attract more attention. This review summarized a series of our works on vascular calcification in recent years，including the update concept of vascular calcification，recent classification and mechanism，and the confusion and hope in experimental and translational researches. This article aiming to promote further studies on the mechanisms and prevention of vascular calcification。