【Objective】Examine the expression of Galectin-3（Gal-3），B cell lymphoma-2 protein（Bcl-2）in epithelial ovari? an cancer tissues with regard to clinicopathological and survival variables，testing whether they can serve as prognostic markers and provide evidence for further research.【Methods】98 EOC tissues and 10 normal ovarian tissues were collected，as well as their clini? cal documents. The expression of Gal-3 and Bcl-2 was tested via immunohistochemical staining analysis. Then the correlation be? tween these two proteins and the clinicopathological and survival variables of these patients were evaluated.【Results】Of the 98 EOC，Gal-3 and Bcl-2 were all cytoplasmic staining. Gal-3 was observed in a majority of the EOC tumor cell proper（75/98， 76.5%）but not in normal ovarian tissues. Bcl-2 was observed in a majority of the EOC tumor cell proper（50/98，51.0%）but not in normal ovarian tissue. Spearman bivariate correlation test show that there was no correlation between the expression Gal-3 and Bcl- 2（P = 0.867）. Gal-3 expression in EOC was associated with histology and platinum sensitivity（P = 0.043，P = 0.038），while Bcl-2 was associated with FIGO stage（P = 0.029）. Cox univariate analysis revealed that Gal?3，Bcl?2 expression，platinum sensitivi? ty，stage were associated with overall survival（P = 0.008，P = 0.021，P < 0.001，P < 0.001）. Further multivariate analysis showed that only Gal?3 expression，platinum sensitivity，stage affected the survival of these patients（P = 0.014，P = 0.021，P < 0.001）. 【Conclusions】The expression of Gal-3 and Bcl-2 in EOC was significantly higher than that in normal ovarian tissue ，supposed that they may involve in the development and progression of EOC. Gal-3 expression was associated with histology，platinum sensitiv? ity and survival，it may be an independent predictive factor for EOC prognosis. There was no correlation between the expressionGal-3 and Bcl-2 in EOC，the functional mechanism between these two protein need further research.