【Objective】To study the change of amplitude-integrated electroencephalography（aEEG）and the relationship with neurological prognosis in children with brain injury.【Methods】This study included 100 brain injured children，100 normal children as the control group. Quantitative aEEG in frontal，temporal，parietal and central lobe were compared. The aEEG in brain injured chil? dren were reexamined after 1 week. The follow-up was observed after 3 months and pediatric cerebral performance category score （PCPC）was recorded for each patient.【Results】The 2-12 months group frontal and temporal lower margin amplitude were signifi? cantly increased，P<0.05，bandwidth in frontal，temporal and central channels were significantly decreased，P<0.05. In 13-35 months group all lower and upper margin amplitudes were significantly higher in brain injury group than normal control group，P< 0.05. In 36-71 months group，frontal，temporal，parietal and central lower margin amplitude were significantly increased，P<0.05. However，only upper margin amplitude in frontal and parietal lobe were significantly different，P<0.05. In 72-155 months group，the lower margin amplitude of frontal，central，parietal and temporal channels were significantly increased，P<0.05；the upper margin amplitude of frontal，central，parietal channels were significantly different，P<0.05；the bandwidth were significantly different in fron?tal and parietal channels，P<0.05. In 156-216 months group，the lower and upper margin amplitude of frontal，central，parietal and temporal channels were significantly increased，P<0.05；the bandwidth were significantly different in frontal channel，P<0.05.Correla? tion analysis shows that the PCPC after 3 months was significantly correlated to upper and lower voltage of parietal channels，r=0.222， 0.219，respectively.【Conclusion】The lower margin amplitude in brain injured children were changed，and the early aEEG of pari? etal channel have predict value for early prognosis。