【Objective】To investigate the prognostic value of 18 F-FDG PET/CT with different metabolic parameters in newly diagnosed limited-disease（LD）small cell lung cancer（SCLC）.【Methods】Retrospective analysis was carried out in the patients between June 2005 to December 2016 in our hospital confirmed of LD SCLC by pathology or cytology and comprehensive imaging. Fifty-four patients were recruited. Record the general characteristics of patients，pre-treatment KPS score，smoking status，weight loss，serum LDH，NSE，OS，PFS. All lesions（primary lesions + metastases）were sketched out within one VOI，and the SUV max ， SUV mean and SUV peak in the VOI were automatically measured and recorded. The automatic measurement was performed by the fixed threshold method. The thresholds of tumor of MTV and TLG were 40% and 50% of SUV max . The TLG and MTV were identified as TLG 40% ，TLG 50% ，MTV 40% and MTV 50% respectively. Kaplan-Meier method was used for survival analysis. All the prognostic factors were analyzed by Cox model.【Result】The median SUV max was 13.92（2.61 ~ 43.28），the median of SUV mean was 8.31（1.71 ~ 26.85） and the median of SUV peak was 10.51（1.49 ~ 27.48）. The median of TLG 40% was 340.22（16.58 ~ 2 827.26），the median of TLG 50%was 215.645（1.70 ~ 2 270.36），the median of MTV 40% was 36.71（1.15 ~ 259.47 cm 3 ），the median of MTV 50% was 19.65（0.93 ~ 1900.00）cm 3 . Univariate and multivariate analysis of metabolic index and prognosis showed that TLG 50% was the prognostic factor of OS（P = 0.013），but not of PFS（P > 0.05）. The SUV max ，SUV mean and SUV peak were not the prognostic factors of OS and PFS（P > 0.05）. 【Conclusion】The volume metabolic parameters TLG 50% was the independent prognostic factor of the overall survival time of the LD SCLC. The volume metabolic parameters（TLG and MTV）of 18 F-FDG PET/CT were related to the prognosis of SCLC，which could provide the basis for individual chemotherapy.