【Objective】 To investigate the prevalence of hyperhomocysteinemia in patients with primary glomerulonephritis and its relationship with target-organ damages.【Methods】 This study included 601 patients with primary glomerulonephritis who were enrolled in the Third Affiliated Hospital of Sun Yat-sen University from May 2010 to March 2015. Demographic and laboratory data were collected. Plasma homocysteine was detected and estimated glomerular filtration rate (eGFR) was calculated. Doppler ultrasound was used to evaluate the changes of cardiac structure and function. Multiple linear regression analyses were used to evaluate the correlation between plasma homocysteine and target-organ damages.【Results】The prevalence of hyperhomocysteinemia was 45.92% (276/601) in patients with primary glomerulonephritis. And the incidence of hyperhomocysteinemia in CKD stage 1

stage 2

stage 3

stage 4

and stage5 was 10.34%

24.53%

57.58%

72.55% and 89.53%

respectively. With the deterioration of renal function

the incidence of hyperhomocysteinemia increased significantly. eGFR in patients with hyperhomocysteinemia was significantly lower than those of normal homocysteine

and the left ventricular mass index and carotid artery intima media thickness were significantly increased. Multiple linear regression analysis showed that homocysteine was associated with impaired renal function. Plasma homocysteine concentration is related to eGFR

calcium*phosphorus

serum uric acid

LDL-C

gender and hemoglobin.【Conclusions】The prevalence of hyperhomocysteinemia in patients with primary glomerulonephritis was 45.92%. Hyperhomocysteinemia was associated with impaired renal function in these patients.