【Objective】To research the sedative effect of intranasal dexmedetomidine and sufentanil for pediatric sedation for stomatological operation of outpatient department.【Methods】60 children undergoing stomatological operation of outpatient depart? ment，age 3 ~ 7 years，weighing 10 ~ 32 kg，of ASA physical status Ⅰ~Ⅱ，were divided into the three groups（n = 20）randomly using a random number table：group dexmedetomidine and sufentanil（group DS），group dexmetomidine（group D），group sufent? anil（group S）. Recorded the children′s behavior using the Ohio State University behavior rating score（OSUBRS），the University of Michigan Sedation Score（UMSS），SBP，HR and side-effects when entry，during and leave operation and in post-anesthesia care unit，side-effects，the satisfaction of stomatological doctors and parents.【Results】The OSUBRS of group DS when entry，during operation were lower than group D（P < 0.01）. The UMSS of group DS were higher than group D and group S when entry and during operation（P < 0.05）. The success rate of group DS was higher than group D and group S（P < 0.01）. There was no different of mean percentage change in systolic blood pressure and heart rate from baseline between group DS and group D（P > 0.05）. There were no instances of respiratory depression，hypotension and bradycadia.【Conclusion】Intranasal dexmedetomidine and sufentanil provides satisfactory pediatric sedation for stomatological operation of outpatient department without side effects such as respiratory depression， bradycadia and hypotension.