Abstract：【Objective】To evaluate the incidence of chromosomal abnormalities and associated abnormalities in prenatally diag? nosed clubfoot，and to determine the prognostic factors as well.【Methods】A total of 89 fetuses with clubfoot diagnosed during Janu? ary 2010 to October 2015 in prenatal ultrasound scan and confirmed postnatally or by autopsy，were selected，within which 16 （18.0%）cases were without other abnormalities and 73（82.0%）cases were with other abnormalities. The associated abnormalities were identified，the correlation with chromosomal abnormalities were analyzed with Fisher analysis and the factors affecting the outcomes were determined with Logistic regression analysis.【Results】Among associated abnormalities，the skeletal abnormalities besides the clubfoot were the most frequently associated anomalies（35，47.9%），and the central nervous abnormalities followed secondly（30，41.1%）. A chromosomal abnormality，with trisomy 18 being the most frequently detected，was identified in 34%（17/ 49）of the clubfoot fetuses with other anomalies，whereas none of chromosomal abnormality was identified in 11 fetuses without other anomalies，a significant different rate of aberrant chromosome noted（P < 0.001）. The survival rate of clubfoot fetuses without other anomalies was higher than that of clubfoot fetuses with other anomalies（50.0% vs 1.3%，P = 0.03）. The conditions of with or without associated anomalies were the independent prognostic factors（P = 0.01），the clubfoot fetuses associated with other anomalies had poor outcomes［OR = 11.9（95% CI：1.8，80.1）］.【Conclusion】Skeletal abnormalities besides the clubfoot were the most frequently associated anomalies. The condition of with or without associated anomalies is the independent prognostic index for fetuses withclubfoot. Aneuploidy were more commonly in clubfoot fetuses with associated abnormalities than in those without other abnormalities. No indication for karyotyping suggests for the clubfoot fetuses without other abnormalities due to the low incidence of associate chromo? somal anomalies.