Abstract：【Objective】To investigate the value of degree centrality（DC），a novel resting-state fMRI parameter，in voxel-wise whole-brain functional networks analysis in primary insomnia（PI）after acupuncture therapy.【Methods】The resting state fMRI were performed in 29 PI patients and 22 age，education，and sex-matched normal healthy subjects. Analysis of DC map changes between the two patient groups and the control group were performed by two sample t test.（threshold at P < 0.05）.【Results】Compared with the control group，patients with PI showed significantly reduced DC value in middle temporal gyrus（MTG. R）；hippocampus（HIP. B）；parahippocampal gyrus（PHG. R）；putamen（PUT. R）；cuneus（CUN. L）.【Conclusions】Changes of DC value occurred in some region of brain in the PI patient groups when compared with the control group. It was indicated that DC，as a novel resting-state fMRI parameter in the voxel-wise whole-brain functional networks，might be an appealing alternative approach for further study on pathologic and neuropsychological states of PI.