32P敷贴联合盐酸卡替洛尔滴眼液局部外涂治疗婴幼儿浅表
血管瘤的疗效观察

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32P敷贴联合盐酸卡替洛尔滴眼液局部外涂治疗婴幼儿浅表血管瘤的疗效观察

更新时间：2023-12-12

- 32P敷贴联合盐酸卡替洛尔滴眼液局部外涂治疗婴幼儿浅表血管瘤的疗效观察
- Observation of Clinical Efficacy of 32P Applicator Combined with Carteolol Hydrochloride Eye Drops Treatment on Infantile Superficial Hemangiomas
- 中山大学学报（医学科学版） 2016年37卷第3期
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- 网络首发：2016-05-20，
  
  纸质出版：2016
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32P敷贴联合盐酸卡替洛尔滴眼液局部外涂治疗婴幼儿浅表血管瘤的疗效观察[J]. 中山大学学报（医学科学版）, 2016,37(3).

Observation of Clinical Efficacy of 32P Applicator Combined with Carteolol Hydrochloride Eye Drops Treatment on Infantile Superficial Hemangiomas[J]. Journal of Sun Yat-sen University (Medical Sciences), 2016, 37(3).
32P敷贴联合盐酸卡替洛尔滴眼液局部外涂治疗婴幼儿浅表血管瘤的疗效观察[J]. 中山大学学报（医学科学版）, 2016,37(3). DOI：

Observation of Clinical Efficacy of 32P Applicator Combined with Carteolol Hydrochloride Eye Drops Treatment on Infantile Superficial Hemangiomas[J]. Journal of Sun Yat-sen University (Medical Sciences), 2016, 37(3). DOI：

摘要

摘要: 【目的】探讨32P敷贴联合盐酸卡替洛尔滴眼液局部外涂治疗婴幼儿浅表血管瘤的临床疗效和安全性?【方法】将235例浅表血管瘤患儿随机分成3组:观察组82例

采用32P敷贴+盐酸卡替洛尔滴眼液联合外涂治疗;对照组77例

采用相同剂量32P敷贴+生理盐水局部外涂治疗;单用组76例

采用盐酸卡替洛尔滴眼液+生理盐水局部外涂治疗

对比观察3组的疗效并比较观察组和对照组的不良反应?【结果】①观察组有效率和显效率分别为97.6%和92.7%

治愈率为86.6%;对照组有效率和显效率分别为94.8%和89.6%

治愈率为81.8%;单用组有效率和显效率分别为86.8%和39.5%

治愈率为6.6%

三组疗效不完全相同(P < 0.001)

其中观察组与对照组疗效相当(P = 0.394)

但均优于单用组(P < 0.001; P < 0.001)?②观察组与对照组的治疗时间中位数分别为9.0个月和10.0个月

两者差异有统计学意义(P < 0.001)

观察组可有效缩短治疗时间?③观察组和对照组的色素脱失发生率分别为19.5%和33.8%;干性皮炎发生率分别为24.4%和40.3%

两组比较差异均有统计学意义(P = 0.042; P = 0.032)

观察组的色素脱失及干性皮炎发生率均低于对照组?【结论】 32P敷贴联合盐酸卡替洛尔滴眼液局部外涂治疗婴幼儿浅表血管瘤整体疗效满意

并可有效缩短治疗时间和减少不良反应的发生

具有临床应用价值?

Abstract

Abstract:【Objective】 To investigate the clinical efficacy of 32P applicator combined with Carteolol hydrochloride eye drops (CHED) treatment for infants with superficial hemangiomas. 【Methods】 235 infants with superficial hemangiomas were randomly divided into three groups: study group (n = 82) were treated by 32P applicator in conjunction with CHED

control group (n = 77) were treated by 32P applicator in conjunction with normal saline and the third group by CHED in conjunction with normal saline. The results of curative effects among the three groups and the adverse reaction between the first two groups were analyzed using rank sum test and test. 【Results】①The cure rate

remission rate and effective rate of the study group were 86.6%

92.7% and 97.6%

respectively

and the corresponding rates of the control group were 81.8%

89.6% and 94.8%

also

the corresponding rates of the third group were 6.6%

39.5% and 86.8%. The effect was not exactly the same as the three groups ( x2 = 119.425

P < 0.001)

nevertheless

the study group got a similar effect with the control group ( x2 = 0.726

P = 0.394 > 0.0167)

but both were better than the third group ( x2 = 88.673

P < 0.001; = 71.972

P < 0.001). ②The period of treatment of the study group and the control group median were 9.0 months and 10.0 months. The difference was statistically significant (Z = 5.455

P < 0.001)

the study group could effectively shorten the treatment period. ③Depigmentation incidence of the study group and the control group were 19.5% and 33.8%

respectively; the incidences of dry dermatitis were 24.4% and 40.3%

the difference was also statistically significant ( x2 = 4.151

P = 0.042 < 0.05; x2 = 4.590

P = 0.032 < 0.05)

the study group depigmentation and dry dermatitis were lower than the control group. 【Conclusion】 32P applicator combined with CHED topical coated of infantile superficial hemangiomas has satisfactory therapeutic effect

can effectively shorten the treatment period

reduce the incidence of dry dermatitis. To sum up

the method is of considerable clinical value.

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