Abstract: 【Objective】 To detect the levels of visfatin and superoxide dismutase (SOD)in plasma of hypertensive and hypertensive diabetic patients.And to explore the correlation between visfatin and SOD in the whole study population.【Methods】 In this cross-sectional study

eighty-eight cases were enrolled

which were divided into hypertensive group (n = 31)

hypertensive diabetic group (n = 31) and control group (n = 26). Blood pressure was obtained from each participant with mercury sphygmomanometer. The levels of visfatin and SOD were measured by ELISA. Meanwhile

the levels of blood glucose

glycosylated hemoglobin A1C (GHbA1c) and lipid profile were detected. 【Results】 The levels of total cholesterol (TC) and body mass index (BMI) were significantly higher in the hypertensive group than those in control group (P < 0.05). The levels of TC

low density lipoprotein cholesterol (LDL-C)

triglyceride (TG)

BMI

waist circumference were significantly higher in the hypertensive diabetic group than those in control group (P < 0.05). The mean plasma concentration of visfatin in both hypertensive diabetic group and only hypertensive group was significantly increased compared to that in the normal group (57.6 ± 16.0

118.3 ± 21.7

vs 21.4 ± 8.2 ng/mL

P < 0.05). While the mean plasma concentration of visfatin in the hypertensive diabetic group was also significantly increased compared to that in the hypertensive group (118.3 ± 21.7 vs 57.6 ± 16.0 ng/mL

P < 0.05). The plasma SOD activity in both hypertensive diabetic group and hypertensive group was significantly decreased compared to that in the normal group(157.1 ± 18.6

145.1 ± 31.4

vs 168.4 ± 23.1 U/mL

P < 0.05). While the plasma SOD activity in hypertensive diabetic group was significantly decreased compared to the hypertensive group (145.1 ± 31.4 vs 157.1 ± 18.6 U/mL

P < 0.05). There was a significantly negative correlation between plasma visfatin concentration and SOD activity in the whole study population (r = -0.390

P < 0.05). 【Conclusion】 The plasma concentration of visfatin is increased in both hypertensive and hypertensive diabetic patients

and more increased in hypertensive diabetic patients. Increased visfatin concentration may be associated with to the reduction of SOD activity.