Abstract: 【Objective】 To analyze the effect of antifungal therapy combined with ventriculoperitoneal (V-P) shunts placement for cryptococcal neoformans meningitis. 【Methods】 Twenty patients confirmed cryptococcus neoformans meningitis accompanying uncontrollable extremely high intracranial pressure

who received V-P shunts operation along with antifungal therapy

were reviewed. Information of the intracranial pressure

count of Cryptococcus neoformans in CSF

main clinical manifestations

before and after the V-P shunt placement

were collected and compared. The occurrences of postoperative complications were also reviewed. 【Results】 All 20 cases experienced a significant decrease of the intracranial pressure after receiving the V-P shunts placement

there is a significant difference in intracranial pressure before and after V-P shunts (P < 0.001). The count of Cryptococcus neoformans in CSF were analogously reduced after operation

there is a significant difference in the count of Cryptococcus neoformans before and after V-P shunts (P < 0.001). Main manifestations such as headaches

visual disorders and dysaudia

hydrocephalus were improved remarkably after operation. The complications accompanied with V-P operation are seldom and can be control. No signs of shunts occlusion

over flow or further Cryptococcus dissemination were found. 【Conclusion】 Antifungal therapy combined with V-P shunts placement can effectually reduce the intracranial pressure and the count of Cryptococcus in CSF

induce remission of the intracranial hypertension

while its side effect is rare and be controllable. Antifungal therapy combined with V-P shunts improves the prognosis of the Cryptococcus neoformans meningitis.