Abstract: 【Objective】 To obtain the lamina cribrosa thickness (LCT) in healthy Chinese subjects in vivo and analyze the impact of gender

eye

age on LCT. 【Methods】 A total of 85 eyes from 85 subjects with no ophthalmic disease history were recruited. Lamina cribrosa image were obtained from all eyes using enhanced depth imaging spectral-domain optical coherence tomography (EDI SDOCT). The LCT was averaged from horizontal and vertical linear scanning. The differences of the LCT of different gender

eye and age were analyzed. The relationships between LCT and intraocular pressure(IOP)

refractive error

as well as age

were analysed. 【Results】 For the whole normal subjects

the overall mean age was 50 ± 18 years

the average LCT was 232 ± 41 μm. No statistically significant difference in LCT was found between the genders (P = 0.71) and different eyes (P = 0.36). According to age

the subjects were divided into three groups: G1(20 ~ 39

40 ~ 59

60 ~ 80 years). The average LCT of the three groups were 211 ± 24

220 ± 30

256 ± 46 μm

respectively

with statistically significant differences among the three groups (P<0.001). Age was positively correlated with LCT (r = 0.46

P < 0.001). IOP and refractive error have no significant effects on the LCT(r = 0.06 ~0.10

P = 0.45) 【Conclusion】 No significant impact of gender and eye was found on LCT. Age may influence the LCT. The impact of age on the lamina cribrosa should be considered when analyzing disease states.