Abstract: 【Objective】 To analyze the imaging manifestation and to summarize differential diagnosis of different sites of gastrointestinal lymphoma. 【Methods】 135 cases with gastrointestinal lymphoma were investigated retrospectively

and the sites

pathologic findings and multi -slice spiral CT imaging manifestations were discussed. All the cases were confirmed by pathology

and were scanned by GE lightspeed 16 or Siemens Somatom Definition 64 CT machines. 【Results】 Stomach was the most common site of primary gastrointestinal lymphoma(69 cases)

followed by intestinal lymphoma(40 cases). Diffuse large B -cell lymphoma(87 cases) and mucosa -associated lymphoid tissue lymphoma ( MALT lymphoma)(24 cases) was the most common pathologic subtypes. Diffuse or focal gastric wall thickening was commonly seen(60 cases)with an absence of obviously stenosis

and “mucosal white line sign” could be seen in 14 cases. Aneurysmal dilation(9 cases)

focal pneumatosis within lesions(3 cases) and “sandwich sign” (2 cases) were the typical CT features of intestinal lymphoma. Colorectal lymphoma(26 cases) was infrequent and its CT findings were analogous to the intestinal lymphoma. 【Conclusion】 Some features in MSCT findings of gastrointestinal lymphoma are typical

especially in ileum. MSCTis helpful in diagnosis and differential diagnosis of gastrointestinal lymphoma.