Abstract: 【Objective】 To investigate the influence of crisis intervention for gray matter volume changes in pilots experienced air accident. 【Methods】 The subjects were 16 pilots experienced air accident and 16 healthy pilots. fMRI scanning were carried on the accident group(before and after crisis intervention) and control group. Gray matter volumes were analyzed using voxel -based morphometry (VBM) as implemented in SPM 5. Control group and air accident group after air accident and the data of air accident group before and after crisis intervention were compared to assess brain alterations. 【Results】The gray matter volumes reduced in bilateral superior frontal gyrus

middle frontal gyrus

hippocampal and anterior cingulate cortex in air accident group compared to controls and increased in bilateral superior frontal gyrus

middle frontal gyrus

hippocampal in the air accident subjects after crisis intervention compared to the air accident subjects before crisis intervention. 【Conclusion】 The gray matter volumes reduced in pilots experienced air accident and increased after crisis intervention.