Abstract: 【Objective】 To probe into the relationship between dyslipidemia and the onset and development of preeclampsia in different classifications through a comparison of the changes in blood lipid indices in the patients with different classifications of preeclampsia during the third trimester of pregnancy. 【Methods】 Data were collected from 198 cases with preeclampsia

of which 108 were diagnosed as mild preeclampsia

54 as late onset severe preeclampsia and 36 as early onset severe preeclampsia. Controls were 200 healthy pregnant women in the same stage of pregnancy who suffered no pregnancy complications. A comparison was made based on the test of serum total cholesterol (TC)

triglyceride (TG)

high -density lipoprotein cholesterol (HDLC)

low -density lipoprotein cholesterol (LDLC)

ApoA and ApoB

and the calculation of AI

LDLC/HDLC and ApoB/ApoA ratios. 【Results】 The levels of TG

Chol

LDLC

ApoB

AI

LDLC/HDLC and ApoB/ApoA were significantly higher in the preeclampsia group than in controls (P < 0.05). The blood lipid indices in particular were significantly abnormal in the severe early onset preeclampsia group (P < 0.05). Area under the ROC curves for predicting severe early onset preeclampsia in the indices of ApoB

AI

LDLC/HDLC and ApoB/ApoA were larger than 0.7 and significant differences were noted in them (P < 0.05). 【Conclusion】 Dyslipidemia plays a significant part in the onset and development of preeclampsia and is closely related to the severity and classification of preeclampsia. The blood lipid indices are of value to the diagnosis of severe early onset preeclampsia. However

this study didn’t generate the optimal cutoff value of the above indices for the prediction of the disease.