【Objective】 To assess the value of plasma miR-499 to predict sepsis with myocardial damage. 【Methods】 The blood specimens from 112 patients with sepsis were collected after admission. According to the occurrence of myocardial damage

they were classified into sepsis with myocardial damage patients (45 cases) and sepsis without myocardial damage patients (67cases). A total of 20 healthy subjects were enrolled as control group. Plasma miR-499 was assessed using real-time polymerase chain reaction. 【Results】 In plasma from sepsis with myocardial damage patients

cardiac myocyte-associated miR-499 was highly elevated

as compared with sepsis without myocardial damage patients and control subjects (P < 0.01). Receiver operating characteristic curve analysis revealed an area under the curve of 0.889 for miR-499. 【Conclusion】 Cardiac damage initiates the detectable release of cardiomyocyte-specific miR-499 into the circulation. Plasma miR-499 can be markers for the diagnosis of myocardial damage after sepsis.