【Objective】 To investigate the serum levels of omentin-1 and vaspin in obese children and their correlation with lipid metabolism.【Method】 59 children participated in the study

30 of which were obese [(9.43±2.02) years old] and 29 were non-obese controls [(10.3±2.2) years old]

without statistical difference in age between the 2 groups. Serum levels of omentin-1 and vaspin were measured by ELISA method. The concentrations of triglyceride (TG)

cholesterol (TC)

fasting plasma glucose (FPG) and fasting insulin (FINS) were also measured. Body mass index standard deviation score (BMI-SDS) and homeostasis model assessment of insulin resistance (HOMA-IR) were calculated for all participants.【Results】 A significant difference of BMI between obese group and control group (24.8 ± 3.4 vs 16.2 ± 3.2

P = 0.000) was observed. Serum levels of TC

LDL-C

FINS

HOMA-IR were significantly higher in obese group than those in control group (all P < 0.05). Serum level of omentin-1 was positively correlated with HDL-C (rs =0.405

P = 0.026) in obese children. The positive correlations between serum omentin-1 and TC((rs =0.614

P < 0.05) in obese girls. The negative correlation between serum vaspin and TC(rs = -0.621

P = 0.031)

LDL-C (rs = -0.678

P = 0.015) in obese girls. 【Conclusions】 Serum omentin-1 levels of obese children and serum vaspin levels of obese girls were associated with lipid metabolism

may take part in the lipid metabolism pathogenesis of children obese. Serum vaspin levels may be relate to gender

puberty.