网络首发:2014-01-20,
纸质出版:2014
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不同滴定终点在无痛取卵术滴定麻醉中的比较[J]. 中山大学学报(医学科学版), 2014,35(1).
Comparison of Different End Points Used in Titrated Anesthesia forPainless Oocyte Retrieval[J]. Journal of Sun Yat-sen University (Medical Sciences), 2014, 35(1).
摘 要: 【目的】 比较经阴道超声引导下穿刺取卵术(TUGOR)麻醉中不同滴定终点的麻醉效果及其对呼吸循环的影响,以探索无痛取卵术麻醉时的最佳滴定麻醉方案。【方法】150例拟行无痛取卵术患者,随机分为3组,MOAA/S评分组(M组)、Ramsay镇静评分组(R组)及脑电双频谱指数组(B组),每组50例。3组病人于静脉注射芬太尼10 μg 1 min后开始诱导,采用丙泊酚滴定给药方式,以1 mg·kg-1·min-1速度持续静脉泵注,分别以MOAA/S评分达1分、Ramsay镇静评分达6分以及BIS值达40~ 50为诱导终点。麻醉维持阶段3组均在丙泊酚4 mg·kg-1·h-1持续静脉泵注的基础上进行调整。记录患者各时间点时平均动脉压(MBP)、收缩压(SBP)、舒张压(DBP)、心率(HR)、脉搏氧饱和度(SPO2)。记录术中不良反应例数并记录操作者和患者术后对麻醉的满意度情况。记录丙泊酚诱导用药量、维持用药量及麻醉诱导时间、维持时间、苏醒时间、离室时间。【结果】MAP的变化在诱导完毕时、进针后3 min R组较B组平稳(P < 0.05),SBP的变化诱导完毕时R组较B组平稳(P < 0.05)。3组间并发症发生率(低氧血症、低血压等)无统计学差异(P> 0.05)。R组、B组操作者及患者术后满意度均高于M组(P < 0.05),而R组和B组间操作者及患者术后满意度无统计学差异(P > 0.05)。3组患者丙泊酚诱导用药量、单位时间维持用药量、用药总量及麻醉诱导时间、苏醒时间、离室时间均无统计学差异(P>0.05)。【结论】 3种滴定麻醉的给药方案在无痛取卵术中均可获得较满意的麻醉。相对地,以Ramsay镇静评分达6分作为滴定诱导终点应用于无痛取卵术滴定麻醉时对患者呼吸循环影响小,获得患者及操作者更高满意度。
Abstract: 【Objective】 To find an appropriate titrated anesthesia protocol forpainless transvaginal ultrasoundguided oocyte retrieval though comparing the anesthesiaeffects and side effects on circulation and respiration among the regimens useddifferent titrated end points. 【Method】 One hundred and fifty patients scheduledfor elective painless oocyte retrieval with ASA physical status Ⅰ~ Ⅱ, were randomlyallocated to three groups (50 patients each). All patients received fentanyl 10 μg intravenously1 minute before induction,then propofol was intravenously administered at the rateof 1 mg·kg-1·min-1 until induction finished. In group M MOAA/S scale reached 1 wasused as induction end point, while in group R Ramsay sedation scale reached 6, andin gourp B the bispectral index reached 40-50. During the maintenance period allpatients received intravenous propofol continuously adjusted at the basic rate of4 mg·kg-1·min-1. MBP, DBP, SBP, SpO2, HR were recorded at different time points.The complications and the satisfaction degree from patients and operator also recorded.The propofol induction dose, maintenance dose, total dose and induction time, awakeningtime, time from awakening to leaving were recorded respectively. 【Result】 In group R ΔMAPand ΔSBP were significantly less than group B (P < 0.05) after induction immediately.three minute after puncture, group R had less ΔMAP than group B (P < 0.05). Thesatisfaction degrees both from patients and operator were higher in group B andgroup R than group M, there was no significant different between group R and groupB. No significant differences were found among the groups in the induction, maintenance,and total dosage of propofol. There were no significant differences in the ΔDBP,HR, SpO2, and induction time, recovery time, time from awakening to leaving andthe rate of complications among groups (P > 0.05). 【Conclusion】 The protocol of titrated anesthesiacan be applied in transvaginal ultrasoundguided oocyte retrieval safely and comfortably.Ramsay scale reaches 6 can be a better induction end point in titrated anesthesiain painless oocyte retrieval.
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