网络首发:2014-07-20,
纸质出版:2014
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Ki-67在木村病患者中的表达和复发相关因素分析[J]. 中山大学学报(医学科学版), 2014,35(4).
Expression of Ki-67 and Recurrence-relatedFactors in Patients with Kimura’s Disease[J]. Journal of Sun Yat-sen University (Medical Sciences), 2014, 35(4).
【目的】 探讨增殖相关抗原Ki-67在木村病(KD)患者中的表达及其与复发相关因素的关系。 【方法】 用链酶素生物素-过氧化物酶(SP法)对40例经手术治疗病理证实为木村病的石蜡组织检测Ki-67的表达,评估其在复发和无复发患者中的表达情况。【结果】在40例患者中,男性37例,女性3例,年龄10 ~ 75岁,34例患者的主要肿块位于头颈部,其余7例主要肿块位于上腭或腹股沟区域,肿块最大直径为6.5 cm。Ki-67在木村病复发患者(11/40)淋巴结组织中(不包括生发中心)表达高于无复发的患者(P< 0.05)。Ki-67表达与性别、年龄、肿块最大直径、发病部位、嗜酸性粒细胞计数及肿块个数无相关性(P > 0.05)。【结论】 Ki-67的表达与木村病的复发相关,可考虑作为预测木村病患者复发的一个有效观察指标。
Abstract:【Objective】 To discuss the expression of proliferation related antigenKi-67 and the correlation between Ki-67expression and recurrence-related prognosis factors in Kimura’sdisease (KD). 【Methods】 Using SP methods to evaluate the expression of Ki-67 in 40 KD cases confirmed by pathological results and comparingthe difference between the recurrent and no recurrent patients of Kimura’s disease.【Results】 Among the 40 cases, males took up 37 cases and other 3 cases were femaleswith an age range from 10-75 years old. The major masses of 34 cases were locatedin head and neck regions, other cases located in hard palate or groin regions. Thelargest mass size was 6.5 cm. Ki-67 had higher expressions(11/40) in the lymph nodes pathological sections (exclude the germinal center) ofrecurrent KD patients than the KD patients without recurrence (P < 0.05). The expressionof Ki-67 had no statistical significance with gender, age,the largest size of mass, mass location, eosinophil counts, and the numbers of mass(P > 0.05). 【Conclusion】 Ki-67 has a correlation with recurrentKD and it suggested Ki-67 could be considerated as an effectivemarker to predict the recurrence of KD.
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