网络首发:2013-11-20,
纸质出版:2013
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肾部分切除术后急性肾损伤早期的监测指标[J]. 中山大学学报(医学科学版), 2013,34(6).
Early Predictors for Postoperative Acute Kidney Injury after Partial Nephrectomy[J]. Journal of Sun Yat-sen University (Medical Sciences), 2013, 34(6).
【目的】 探讨肾部分切除术后急性肾损伤指标早期监测效能。【方法】76例肾癌患者在我院接受肾部分切除术,术后根据急性肾损伤诊断标准将患者分为两组:急性肾损伤组和非急性肾损伤组,采用受试者工作特征曲线评价急性肾损伤生化指标判断急性肾损伤的效能。【结果】 24例(31.6%)患者术后发生急性肾损伤,其余52例(68.4%)患者术后未发生肾损伤,肾损伤组患者术中肾血管阻断的时间(min)较非肾损伤组长(30 ± 19 vs 24 ± 9, P = 0.03),肾损伤组有5例(20%)患者术中接受输血而非肾损伤组仅有8例(15%)患者接受输血(P = 0.011),肾损伤组患者住院时间较非肾损伤组患者长(P = 0.017)。术后24 h和48 h血清胱抑素C水平具有良好预测急性肾损伤效能,其AUC分别为0.790 [95%CI 0.688 ~ 0.893, P = 0.000 )和0.754 (95% CI 0.646 ~ 0.863, P = 0.000)。多元回归分析发现术后急性肾损伤危险因素包括输血 (P = 0.028)和术后24 h血清胱抑素C浓度(P = 0.018)。【结论】术后血清胱抑素C可能是肾部分切除术后急性肾损伤早期监测指标,输血和术后血清胱抑素C浓度可能是术后急性肾损伤独立危险因素。
【Objective】 To explore the ability of biomarkers in predicting acute kidney injury (AKI) after partial nephrectomy. 【Methods】 A prospective study of 76 patients undergoing partial nephrectomy in our center were enrolled. The patients were divided into two groups according to the situation of acute kidney injury: acute kidney injury group (AKI group) and no acute kidney injury group (no AKI group). Receiver operator characteristic (ROC) curves were generated and the area under the curve (AUCs) was compared. 【Results】 Twenty-four (31.6%) subjects developed AKI while fifty-two (68.4%) subjects developed no AKI. Clamping time in AKI group was longer than that in no AKI group (30 ± 19 min vs 24 ± 9 min, P = 0.03). Five (20%) patients received blood infusion in AKI group while eight (15%) patients received blood infusion in no AKI group (P = 0.011). AKI was associated with prolonged hospitalization (P = 0.017). The area under ROC curve for AKI prediction was 0.790 [95% confidence interval (CI) 0.688 to 0.893, P = 0.000] for serum cystatin C 24 hours after surgery and 0.754 (95% CI 0.646 to 0.863, P = 0.000) for serum cystatin C 48 hours after surgery. Multivariate regression analysis showed transfusion (coefficient 0.287,P = 0.028) and 24 hours serum cystatin C (coefficient 2.441,P = 0.018) correlated with AKI. 【Conclusions】 Postoperative serum cystatin C may be an early predictor for AKI after partial nephrectomy. Transfusion and postoperative serum cystatin C may be independent risk factors for AKI after partial nephrectomy.
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