网络首发:2014-01-20,
纸质出版:2014
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两种方法联合评估新疆维吾尔族OSAHS患者的听觉功能[J]. 中山大学学报(医学科学版), 2014,35(1).
Evaluate Auditory Function for OSAHS patients in Xinjiang Uyghur NationalityVia Two Methods[J]. Journal of Sun Yat-sen University (Medical Sciences), 2014, 35(1).
摘 要: 【目的】 为了评估阻塞性睡眠呼吸暂停低通气综合征(OSAHS)对新疆维吾尔族听觉功能的影响,探讨其损害部位及特点。【方法】 70例维吾尔族成人经多导睡眠监测系统(PSG)检查分为轻、中、重组OSAHS患者,选取35例维吾尔族健康成人为对照组。所有研究对象分别进行畸变产物耳声发射(DPOAE)及听性脑干反应(ABR)检测及分析,通过比较DPOAE的反应幅值及ABR的各波潜伏期和波间期变化评估听觉功能损害情况。【结果】OSAHS患者 DPOAE各频率(750 ~ 8 000 Hz)的反应幅值较对照组降低,差异有统计学意义(P < 0.05)。经ABR检测,轻中度OSAHS组与对照相比,波Ⅰ、Ⅲ、Ⅴ潜伏期及Ⅰ-Ⅲ、Ⅰ-Ⅴ波间期的延长,差异有统计学意义(P< 0.05);重度OSAHS组的各波潜伏期及波间潜伏期均较对照延长,差异有统计学意义(P < 0.05);轻中度组与重度组OSAHS相比波Ⅰ、Ⅲ潜伏期及Ⅰ-Ⅴ波间期的延长,差异有统计学意义(P< 0.05)。OSAHS的病情程度与BMI、阻塞部位、鼾声指数、最低血氧饱和度关系密切(P < 0.05),并且不同病情程度的OSAHS患者的DPOAE检出率、ABR异常率相比较差异有统计学意义(P< 0.05)。【结论】 OSAHS对维吾尔族听觉功能有损害,其中耳蜗主动听觉功能降低,尤以高频听力下降明显,可能合并听觉传导通路中的听神经中枢段及听觉中枢的损害,需联合DPOAE和ABR综合评估筛查听觉损害,尽早发现,及时干预。
Abstract: 【Objective】 To evaluate whether OSAHS affects auditory function, furthermore,investigate damaged sites and characteristics in Xinjiang Uyghur nationality. 【Methods】Total of 70 Uyghur adults with OSAHS and 35 healthy Uyghur adults as control group,which were monitored and diagnosed by polysomnography. After that, OSAHS subjectswere grouped into mild, moderate and severe degrees. The damage of hearing functionfor all subjects was evaluated by DPOAE (distortion-product otoacoustic emissions)and ABR (auditory brainstem response) detections. 【Results】 The values of DPOAE(750 to 8 000 Hz) were decreased, difference was statistically significant betweenOSAHS and control group (P < 0.05). Via ABR test, there was statistical significance(P < 0.05) between mildtomoderate OSAHS and control group in the latency of waveI, III and V, the interpeak latency of IIII, IV; In the severe group, wave latencyand interpeak latency were significantly longer than control group (P < 0.05); Mildtomoderategroup compared with severe one, difference of wave I, III latency and interpeaklatency of IV with statistical significance (P < 0.05). Degrees of OSAHS are closelycorrelated to BMI, obstructive site, snoring index, lowest oxygen saturation, inaddition, detected rate of DPOAE and abnormal rate of ABR exist statistical difference(P < 0.05). 【Conclusion】 OSAHS can lead to the auditory function damage in Uyghurnationality. Active hearing function of cochlear decline, especially in high frequencyhearing loss obviously, accompanied by impairment of central part of auditory nerveand/or the auditory center. DPOAE and ABR detections are necessary to be combinedto evaluate hearing function damage among Uyghur OSAHS, which could contribute toscreen out early hearing damage and to timely therapeutic intervention.
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