Abstract: 【Objective】 To analyze the etiology or incentive

frequency distribution and extent of hearing loss deterioration during treatment in sudden deafness patients. 【Methods】 A retrospective analysis of the pure tone threshold of 54 sudden deafness patients whose hearing loss deteriorated during treatment from August 2009 to June 2013 was conducted. The probability and extent of every hearing deteriorating frequency were calculated based on their audiogram. Thorough medical history was asked and necessary examinations were conducted to investigate the etiology or incentive. 【Results】 Part of the sudden deafness patients suffered hearing loss deterioration during treatment (7.55%)

all of them happened between 3days to 16 days

26 patients suffered in their left ears

and the other 28 in their right ears. The probability and extent of every frequency deterioration

125 Hz

88.9% (48/54)

28.3 ± 16.2 dB; 250 Hz

94.4% (51/54) 29.0 ± 18.8 dB; 500 Hz

81.2% (44/54)

26.6 ± 18.1 dB; 1 kHz

55.6% (30/54) 25.2 ± 17.2 dB; 2 kHz

44.4% (24/54) 25.4 ± 17.6 dB; 4 kHz

22.2% (12/54) 26.3 ± 18.0 dB; 8 kHz

18.5% (10/54) 25.5 ± 17.4 dB. There was no significant difference between the extent of every frequency

(P = 0.955) but the difference of the probability was significant. (P = 0.000). 13 patients (24.1%) suffered from insufficient rest and mental stress; 3 patients (5.6%) complained the accompany symptoms; 1 patient (1.9%) was attributed to corticosteroid reduction. Identified etiology or incentive were not found in the 37 patients.【Conclusions】 Part of the sudden deafness patient suffered hearing loss aggravation during treatment. There is a downtrend from low frequency to high frequency. The probable etiology or incentive of the hearing loss deterioration include lack of rest and mental stress; the aggravation of the accompanying symptoms; corticosteroid reduction; gradually sudden deafness; inner ear hemorrhage due to thrombolytic therapy

ischemical reperfusion injury

worsen of membranous labyrinth hydrops.