Abstract: 【Objective】 To detect airway remodeling in the airways of patients with chronic obstructive pulmonary disease (COPD) by using ultrasound (EBUS)

and to explore the relationship between lung function index by Spirometer and airway diameter line by EBUS. 【Method】 Forty subjects were divided into two groups: COPD group with 20 patients and control group with 20 patients.All subjects underwent the EBUS and lung function test. By EBUS

subjects’ left main bronchus

left upper lobe bronchus and right middle bronchial and lower lobe basal segment bronchial(B10) were detected

which included measuring the following parameters: the wall thickness(T)

mucous membrane layer thickness (TL1)

thickness of submucosa (TL2)

outer membrane layer thickness (TL3 ~ L5)

lumen area (Ai) and tube wall area (WA). 【Results】 Right main bronchus:in the COPD group

T

TL1

TL2

WA were greater than them in the control group

and P < 0.05; In two groups TL3 ~TL5 and Ai were similar. Upper right lobe bronchus: in COPD group

T

TL1 and WA were greater than the control group; In two groups

TL2

TL3 ~ L5

Ai were similar. Right B10 and right middle bronchial

in COPD

T

TL1

TL2 and WA were greater and Ai were smaller than the control group

and P<0.05; TL3 ~ L5 were similar. Correlation analysis: Left main bronchus lines were no significant correlation between lung function. Leaf thickening of bronchial mucosa and submucosa layer being associated with COPD limited airflow

the results are as follows: in COPD patients

TL1 of upper left lobe bronchus with FEV1

FVC (r = -0.517 ~ -0.448) showed a negative correlation; TL1 of right middle bronchial with FEV1/FVC (r = -0.533 showed a negative correlation; TL2 and FEV1 and FVC(r = -0.590 ~ 0.507) also showed negative correlation. In right B10

compared with the leaf bronchial

thickness of mucosa and submucosa layer were stronger correlation with limited airflow; Wall thickness and area were weaker correlation with limited airflow than the mucosa (L1) and submucosa (L2).The results were as follows: in right B10 bronchus T and FEV1

FEV1%

FVC and FVC% (r = -0.519 ~ -0.504) showed a negative correlation; TL1 and FEV1

FEV1%

FVC

FVC% and FEV1/FVC (r = -0.902 ~ -0.566) showed a negative correlation; TL2 and FEV1

FEV1% and FVC% (r = -0.597 ~ -0.472) showed a negative correlation; Ai with FEV1

FEV1%

FVC and FVC% (r = 0.457 ~ 0.527) were positively correlated; WA and FEV1%

FVC% (r = -0.502 ~ 0.470) showed a negative correlation. 【Conclusion】 In the COPD patients

1 ~ 4 grade bronchial airway wall become thickening

especially the mucosa and submucosa

lumen having a tendency of narrow

the airway diameter line with limited airflow having certain correlation

and the relationship in the classification of higher bronchus is obvious; EBUS relatively noninvasive

can accurately reflect the actual changes thickness of each layer in the airway wall. It is the ideal airway morphology detection methods

and hopes to become a means of the diagnosis of COPD airway remodeling.