Abstract:【Objective】 To study the effect of exenatide on PCOS IR and reproductive endocrine hormone in PCOS rats. 【Methods】We used the dehydroepiandrosterone (DHEA) to establish female PCOS rats modeland the rats were randomly divided into exenatide treatment group (Group EX

n = 10)

metformin treatment group (Group MF

n = 10)

PCOS group (Group PCOS

n = 9)

and normal control group (Group NC

n = 10). The EX group was administered exenatide hypodermic injection once daily

while MF group was given metformin per os dissolved in distilled water once daily

the treatment period was four weeks. The Group PCOS and Group NC were given the normal diet. Histologic detection of ovaries by HE staining the ovary tissue of every group rats were observed their pathohistology by lighter microscope. Detecting the T

FSH

LH

OGTT

FINS of rats serum

and using HOMA-IR to assess insulin resistance. 【Results】 1. The rat model of PCOS was successfully established. 2. After drug intervention the values of T and LH: MF

EX

NC group were lower than PCOS group (P < 0.05). LH/FSH:EX group were lower than PCOS group (P < 0.05). 3. After drug intervention the values of FPG

FINS

HOMA-IR: MF

EX

NC group were lower than PCOS group (P < 0.05). The values of 30minPG: MF group was higher than EX

PCOS

and NC group (P < 0.05). The values of 1hPG: MF and PCOS group were higher than EX and NC group (P < 0.05). The values of 2hPG: PCOS group was higher than EX

MF

and NC group (P < 0.05).【Conclusions】 Exenatide improves insulin resistance and reproductive in PCOS rats

reducing HOMA-IR

LH/FSH ratio and androgen levels

ameliorate endocrine disorders

thereby improving ovarian function and promote follicle development

providing new avenues for the treatment of PCOS.