Abstract: 【Objective】 To study the level of the MCP -1

HDL2

and HDL3 and analyze the relationship between MCP -1 and HDL2

HDL3

to explore the effect of inflammatory and HDL particle size in premature coronary artery disease. 【Methods】 A total of 236 CAD patients who accepted the examination of coronary angiography of coronary artery from the department of cardiology of Sun Yat -sen Memorial Hospital

Sun Yat -sen University

including PCAD group (n = 108) whose males aged ≤55 years and females aged ≤65 years and LCAD group (n = 128) whose males aged > 55 years and females aged > 65 years. Recruited 96 healthy population whose males aged ≤55 years and females aged ≤65 years as young healthy group. Peripheral venous blood were collected and separated the serum from all participants

the separation of HDL subfractions (HDL2

HDL3) was carried out by enzymatic methods. The levels of MCP-1 was detected by enzyme-linked immunosorbent assay (ELISA). 【Results】(1) The level of HDL2 was significantly decreased in PCAD group compared with LCAD group and young healthy group. The level of MCP -1 was significantly increased in PCAD group compared with young healthy group (both P < 0.05). (2) MCP -1 as dependent variable

HDL

HDL2

HDL3 as independent variable

multiple linear regression analysis showed that the level of HDL2 was negatively related with the level MCP -1 in PCAD group

while HDL

HDL3 were irrelevant. (3) Logistic regression model was used to assess the association with PCAD patients

in which BMI

diabetes

family history of CAD

was positive related with PCAD

while the level of HDL

HDL2 was negative.【Conclusion】 The decrease of HDL2

increase of MCP -1 and the negative relationship between MCP -1 and HDL2

prompted that the inflammatory response to increase by PCAD patients. Decline of HDL2 anti -inflammatory function contributes the pathogenesis of atherosclerosis

that maybe the risk factors of PCAD.