Abstract: 【Objective】 To measure the total liver fat in subjects with normal tolerance and the patients with impaired glucose tolerance (IGT) by using MR and to explore the correlations between liver fat content and clinical index in these two groups. 【Methods】 63 subjects were enrolled and each of them underwent upper -abdominal MRI examination that involved T1WI VIBE Dixon sequence. 21 was clinically diagnosed with IGT (collectively as IGT group) while 42 showed normal glucose tolerance

( collectively as NGT group). NGT group was further divided into NGT -Fat (BMI ≥ 25

18 subjects) and NGT -Lean (BMI < 25

24 subjects). The total liver fat contents was measured and compared with clinical findings and laboratory results in order to determine statistical correlations between these parameters. Differences among IGT

NGT -Fat and NGT -Lean groups were evaluated. 【Results】 For all the subjects

fat volume fractions (FVF) ranged from 4.2% to 28.8%

positive correlations was observed with BMI(P = 0.005)

waist hip ratio (WHR )(P = 0.044)

low density lipoprotein -cholesterol (LDL -C)(P = 0.033)

fasting plasma insulin (FPI) (P = 0.018). homeostasis model assessment insulin resistance (HOMA -IR) (P = 0.018) and homeostasis model assessment (HOMAβ) (P = 0.005). FVF of IGT group (P = 0.003) and NGT -Fat group (P = 0.006) were significantly higher than those of NGT -Lean group. 【Conclusion】 People with higher BMI

WHR and LDL -C levels tend to have higher liver fat content. Patients with BMI≥25 are more likely to develop to IGT. Patients with higher FVF showed higher resistance to insulin

thus obtained a higher risk of developing type 2 diabetes mellitus.