Abstract:【Objective】 To evaluate the detected diagnostic value of double-contrast enhanced ultrasound (D-CEUS) in periampullary region lesions and compare with that of conventional ultrasound (US) and hydrosonography of gastrointestinal tract (GI-US). 【Methods】 Clinical data of 67 patients with periampullary lesions who received examinations of US

GI-US

and D-CEUS both in The Third Affiliated Hospital of Sun Yat-sen University were analyzed retrospectively. The informed consents of all patients were obstained and the ethical committee approval was received. There were totally 67 lesions in 69 patients

including 40 malignant lesions (19 duodenal papillary carcinoma

9 distal common bile duct carcinoma

6 pancreatic uncinate process carcinoma

6 ampullary carcinoma) and 29 benign lesions (28 distal common bile duct stones and 1 villus-tubiform adenoma). All the lesions were confirmed by surgical pathological biopsy or choledochoscopy. Three ultrasound modalities were made comparison between each other in the detection rate

clarity degree and definite diagnosis rate of the above periampullary region lesions. 【Results】 The detection rate of US

GI-US

and D-CEUS were 59.42%

95.65%

and 98.55% and the clarity degree of each modality were 17.39%

60.87%

and 84.06%

respectively. D-CEUS can highly raise the display capacity compared with US (P < 0.001). Although D-CEUS appeared with no statistical differences (P = 0.619) compared with GI-US

it has significant differences in clarity degree of images (P = 0.006). 【Conclusions】 D-CEUS can improve the detected diagnostic capacity of periampullary lesions as an important imaging modality for periampullary obstructive diseases.