选择性α-受体阻滞剂治疗良性前列腺增生症下尿路症状
对男性射精功能影响的Meta分析

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选择性α-受体阻滞剂治疗良性前列腺增生症下尿路症状对男性射精功能影响的Meta分析

更新时间：2023-12-12

- 选择性α-受体阻滞剂治疗良性前列腺增生症下尿路症状对男性射精功能影响的Meta分析
- Impact of Alpha-blockers Treatment for Male Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia on Ejaculatory Function: A Meta-Analysis
- 中山大学学报（医学科学版） 2014年35卷第6期
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  中图分类号： R69
- 网络首发：2014-12-05，
  
  纸质出版：2014
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选择性α-受体阻滞剂治疗良性前列腺增生症下尿路症状对男性射精功能影响的Meta分析[J]. 中山大学学报（医学科学版）, 2014,35(6).

Impact of Alpha-blockers Treatment for Male Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia on Ejaculatory Function: A Meta-Analysis[J]. Journal of Sun Yat-sen University (Medical Sciences), 2014, 35(6).
选择性α-受体阻滞剂治疗良性前列腺增生症下尿路症状对男性射精功能影响的Meta分析[J]. 中山大学学报（医学科学版）, 2014,35(6). DOI：

Impact of Alpha-blockers Treatment for Male Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia on Ejaculatory Function: A Meta-Analysis[J]. Journal of Sun Yat-sen University (Medical Sciences), 2014, 35(6). DOI：

摘要

摘要:【目的】通过对选择性α-受体阻滞剂类药物(ABs)治疗良性前列腺增生症(BPH)下尿路症状时引起男性射精功能障碍的相关文献进行meta分析

评价ABs对男性射精功能的影响?【方法】检索从建库至2014年3月的Cochrane 图书馆临床对照试验库(CENTRAL)?PubMed?BMJ-Clinical Evidence?CNKI中国知网?万方数据库和维普中文科技期刊数据库等

获取选择性α-受体阻滞剂类(ABs)药物治疗BPH时导致射精功能障碍的相关文献? 【结果】共检索到528篇文献

对符合纳入标准的16篇RCT文献进行Meta分析?16篇RCT文献中所有文献均采用随机分组方法

14篇采用安慰剂对照

10篇采用双盲法?BPH患者服用ABs药物比安慰剂更易导致异常射精(OR = 5.82

P = 0.0004 < 0.05);亚组分析显示

西洛多辛与坦索罗辛的异常射精发生率明显高于安慰剂

西洛多辛对比安慰剂(OR = 32.52

P < 0.00001)

坦索罗辛对比安慰剂(OR = 6.89

P < 0.0001);特拉唑嗪与安慰剂在异常射精发病率上无明显差异(OR = 1.50

P = 0.81)

多沙唑嗪与安慰剂在异常射精发病率上无明显差异

(OR=0.74

P = 0.71);药物间比较显示

坦索罗辛在异常射精发病率上明显小于西洛多辛(OR = 0.10

P < 0.000 01)

坦索罗辛在异常射精发病率上对比多沙唑嗪无明显差异(OR=1.23

P = 0.76)

增加坦索罗辛的剂量会增加异常射精的发病风险(OR=0.10

P < 0.000 01)?【结论】长期超常规剂量或连续服用选择性α-受体阻滞剂类(ABs)药物治疗男性良性前列腺增生症下尿路症状时可增加患者发生射精功能障碍的风险

尤其是逆行射精?其中高选择性α-受体阻滞剂(西洛多辛与坦索罗辛)较一般选择性α-受体阻滞剂更易导致射精功能障碍?本研究可为良性前列腺增生症LUTS症状患者合理选择α-受体阻滞剂类药物提供参考?

Abstract

Abstract: 【Objective】 To provide a meta-analysis of the available randomized clinical trials (RCTs) reporting the impact of Alpha-blockers treatment for LUTS due to BPH on ejaculatory function.【Methods】 According to the requirements of meta-analysis

a literature search about Alpha-blockers therapy in LUTS due to BPH was performed among Cochrane clinical controlled trials database

PubMed

BMJ-Clinical Evidence

CNKI

VIP and Wanfang data from the establishment of the database till May 2014. 【Results】 A total of 528 articles were included

16 RCTs were enrolled for meta-analysis. 14 articles used Placebo-and Active-Controlled

10 articles used double-blind method. Ejaculatory dysfunction was significantly more common with alpha-blockers (ABs) than with placebo (OR=5.82

P=0.0004<0.05). In particular

considering Tamsulosin (OR=6.89

P < 0.000 1) or Silodosin (OR = 32.52

P < 0.000 01); conversely

Doxazosin and Terazosin were associated with a risk similar to placebo. Comparing in the different Alpha-blockers

Tamsulosin associated with significantly lower risk of ejaculatory dysfunction than Silodosin (OR=1.50

P = 0.81); but Tamsulosin had no significantly difference with Doxazosin; more dose of the Tamsulosin is effective over time

greater is the incidence of ejaculatory dysfunction. 【Conclusions】 More the Alpha-blocker is effective over time

greater is the incidence of ejaculatory dysfunction

retrograde ejaculation especially. And high selectivity of alpha-blocker (Silodosin and Tamsulosin) was more likely to lead to ejaculatory dysfunction. These data can be relevant both for drug selection and patients counseling.

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