Abstract: 【Objective】 Fungal liver infection in leukemia patients are extremely rare. The purpose of the study was to improve the diagnostic efficacy of CT for such diseases by summarizing the CT features of fungal liver infection in leukemia patients proved by pathology. 【Methods】 Sixteen leukemia patients with fungal liver infection proven by pathologically were collected and underwent non-enhance and enhance CT scanning

retrospectively analyze the characteristics of CT findings. 【Results】 Nine patients suffered hepatomegaly (56%). Based on CT findings

five different types of lesions were found: Type Ⅰ showed simple low density lesions during unenhanced phase

lack of enhancement during HAP and slight enhancement during PVP. Type Ⅱ showed ring sign

edge enhancement during HAP was found

but it would be equal density during PVP. Target sign was the main character of Type Ⅲ

and bull eye sign was found in type Ⅳ

while Type Ⅴ appeared as petal form multinodular confluent tumor. In all 16 patients

Type Ⅰ(1/16)

Type Ⅱ(7/16)

Type Ⅲ(5/16)

type Ⅳ(1/16)

and Type Ⅴ(1/16) were found

while 1 patient image contained Type Ⅱ and Type Ⅲ simultaneously. 【Conclusions】 Fungal liver infection in leukemia showed certain pattern on CT imaging

and CT would contribute to early diagnose and monitor the efficacy of treatment.