【Objective】 Laparoendoscopic single-site (LESS) surgeries have their own difficult surgical characteristics which need to be improved. In this study

we retrospectively reviewed the cases of the retroperitoneal LESS resection of adrenal lesions and compared with standard laparoscopic surgeries.【Methods】 Retroperitoneal LESS resection of adrenal lesions was performed in 23 consecutive patients with adrenal lesions

which were named as the study group. Surgical indices were recorded and compared with the indices of 22 cases obtained standard laparoscopic operations performed by the same surgeon. Totally 45 patients were involved. The differences of the mean operative times

blood losses

analgesia drugs used after operations and the median maximal diameters of the resected tumors between the two groups were compared by statistics methods. 【Results】 All operations were completed uneventfully. No major complications were recorded. An extra trocar was added in one patient in the LESS group. For the LESS and standard laparoscopic operations

respectively

the mean operative times were (105 ± 43) min and (102 ± 37) min (P﹥0.05)

the mean blood losses were (35 ± 30) mL (range

5 to 100 mL) and 30 ± 31 mL (range

10 to 120 mL) (P﹥0.05)

the analgesia drugs used after operations in two groups were (1.2 ± 1.1) and (2.1 ± 1.4) morphine equivalents (P﹤0.05). The median maximal diameters of resected tumors were (2.7 ± 0.8) cm (range

1.3 to 3.8 cm) and (2.8 ± 0.9) cm (range

1.2 to 4.5 cm) (P﹥0.05). 【Conclusions】 The technique of LESS can achieve comparable surgical efficiency to standard laparoscopy in treating small adrenal lesions

and has certain advantages in incision beauty and wound pain.