Abstract: 【Objective】 To evaluate whether high sensitivity C-reactive protein (hs-CRP) is a predictive factor in patients with squamous cervical cancer. 【Methods】 We retrospectively analyzed the records of 989 patients with squamous cervical cancer treated in our institution for their initial serum hs-CRP level before therapy. Mann-Whitney U and K independent samples test were used to evaluate the association of the hs-CRP levels with variables associated with a poor prognosis. Kaplan-Meier analysis and Cox proportional hazards model were used to perform univariate and multivariate analyses. Healthy control group was 989. 【Results】 The median hs-CRP serum level in patients with squamous cervical cancer was higher than the control group (2.72(2.48) mg/L vs 1.76(4.92) mg/L

P=0.011). Hs-CRP serum levels were significantly associated with advanced tumor stage

histological grade

lymph node involvement

the depth of cervical stromal invasion

parametrial involvement

and patients’ age. Tumor stage

histological grade

lymph node involvement

the depth of cervical stromal invasion

parametrial involvement

patients’ age

hs-CRP and SCCA serum levels were correlated with overall and disease-free survival; tumor stage

lymph node involvement

and hs-CRP serum level were independently prognostic factors. The rank correlation analysis showed that there was a positive correlation between serum hs-CRP and SCCA [rs = 0.206

P < 0.000(two-sides)]. 【Conclusion】 Hs-CRP serum levels may work as a prognostic parameter in patients with cervical cancer. Further investigation is deserved to validate its value.