网络首发:2013-11-20,
纸质出版:2013
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变应性鼻炎相关因素的Logistic回归分析[J]. 中山大学学报(医学科学版), 2013,34(6).
Logistic Regression Analysis of Related Factors in Allergic Rhinitis[J]. Journal of Sun Yat-sen University (Medical Sciences), 2013, 34(6).
【目的】 分析变应性鼻炎(AR)发病相关因素。【方法】 采用病例对照研究,通过系统抽样的方法,详细记录AR患者和健康者的性别、年龄、文化程度、上班/上学交通工具、职业接触粉尘史、既往史、饮食习惯、家族史、居住/工作环境。回归分析采用二分类Logistic(Forward: Conditional)法。【结果】 获得的AR发病相关因素的Logistic回归预测方程是:Logit(P)=-6.909-0.063X1+1.095X2+2.319X3+2.437X4+2.281X5+0.878X6+1.129X7,其中X1、X2、X3分别为文化程度为大专、高中及初中,X4、X5分别为父亲有过敏性疾病史(包括AR、支气管哮喘和过敏性遗传性湿疹)和母亲有过敏性疾病史(包括AR、支气管哮喘和过敏性遗传性湿疹),X6、X7分别为居住/工作环境不经常开窗通风及不经常清洁。其中,文化程度为高中、初中者患AR的危险分别是文化程度为本科或以上者的2.989倍(95%CI 1.145 ~ 7.803)和10.169倍(95%CI 2.451 ~ 42.193),父亲有过敏性疾病史者患AR的危险是父亲无过敏性疾病史者的11.437倍(95%CI 2.715 ~ 48.181),母亲有过敏性疾病史者患AR的危险是母亲无过敏性疾病史者的9.784倍(95%CI 2.475 ~38.682),居住/工作环境不经常清洁者患AR的危险是经常清洁者的3.093倍(95%CI 1.352 ~ 7.079)。【结论】 文化程度为高中、初中,父母亲有过敏性疾病史,居住/工作环境不经常清洁是AR发病的相关因素。
【Objective】 To obtain related pathological factors in allergic rhinitis (AR).【Methods】 The occupational dust exposure, past history (including disease history: asthma, atopic eczema, rhinosinusitis, pneumonia, bronchitis and other disease; drug allergic history, smoking history and drinking history), parental allergic disease history (including AR, asthma and atopic eczema), indoor environmental situation, the vehicle and the dietary habits, and the general social demographic characters of 101 AR patients and 121 healthy controls were recorded and assessed. All the results were analyzed statistically.【Results】 The logistic regression predictive equation for allergic rhinitis was: Logit(P)= -6.909-0.063X1 + 1.095X2 + 2.319X3 + 2.437X4 + 2.281X5 + 0.878X6 + 1.129X7, in which X1, X2, and X3 meant educational level (pre-university education, senior middle school and junior middle school, respectively), and X4 and X5 meant paternal and maternal allergic diseases’ history which including AR, asthma and atopic eczema, respectively, and X6 and X7 meant seldom window ventilated and seldom cleaning in the indoor environment, respectively. Factors related to AR included senior middle school educational level [P = 0.025, OR = 2.989, 95% confidence interval (CI) were 1.145-7.803], junior middle school educational level (P = 0.001,OR=10.169,95% CI were 2.451-42.193), paternal allergic diseases’ history (P = 0.001, OR = 11.437, 95% CI were 2.715-48.181), maternal allergic diseases’ history (P = 0.001, OR=9.784, 95% CI were 2.475-38.682) and seldom cleaning in the indoor environment (P = 0.008,OR=3.093, 95% CI were 1.352-7.079). 【Conclusion】 Senior middle school educational level, junior middle school educational level, paternal and maternal allergic diseases’ history, and seldom cleaning in the indoor environment were related to AR.
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