Abstract: 【Objective】 To investigate the assisted reproductive outcomes of thalassemia carriers undergoing preimplantation genetic diagnosis with routine ovarian stimulation

and to explore the ovarian response characteristics of thalassemia carriers and the proper ovarian stimulation intensity if they sought after PGD treatment. 【Method】 We reviewed the outcome of couples that both carried mutation attributed to thalassemia (study group) and couples in which with male factors underwent ICSI (control group). All patients received routine ovarian stimulation. Ovarian response

oocyte number and pregnancy outcome were recorded. 【Results】 No difference was observed for patient demographic and baseline clinical characteristics. No difference in COS parameters was observed for the total dose of recombinant FSH and the number of retrieved oocytes. However

the number of embryos transferable was significant lower in study group than in the control (P = 0.021). For both groups

pregnancy outcomes including clinical pregnancy rate and live birth rate were similar per cycle. 【Conclusion】 Ovarian response is not impaired by thalassemia carrier status and satisfactory clinical outcomes could be achieved with routine ovarian stimulation for thalassemia carriers undergoing preimplantation genetic diagnosis.