网络首发:2013-07-20,
纸质出版:2013
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复方短效口服避孕药在未婚女性流产后服务中的优势及安全性[J]. 中山大学学报(医学科学版), 2013,34(4).
Advantages and Safety of Use of Short-acting Combined Oral Contraceptive Post Abortion in Unmarried Women[J]. Journal of Sun Yat-sen University (Medical Sciences), 2013, 34(4).
【目的】 比较、探讨复方短效口服避孕药(短效COC)在未婚女性人工流产后服务中应用的优势及安全性。【方法】 110例行人工流产术的未婚女性,随机分为:口服避孕药(达英-35)组43例、人工周期替代药(克龄蒙)组35例、空白对照组32例。达英-35组和克龄蒙组人流术后均即时开始服药,建议连用3个周期,三组均予流产后相关服务。术后随访观察术后出血时间、月经转归时间、月经紊乱发生率、术后妊娠、子宫内膜厚度,药物不良反应、评价用药依从性。【结果】 达英-35组坚持服用3周期的共25例,其术后阴道出血持续和术后第一次月经转归时间均较空白对照组短(P < 0.05);术后3个月内月经紊乱发生率较克龄蒙组和空白对照组低(P < 0.05)。克龄蒙组坚持服用3周期的共22例,其术后阴道出血持续时间、术后第一次月经转归时间、术后3个月内月经紊乱发生率与空白对照组差异无统计学意义(P > 0.05)。达英-35组术后3个月内无再次妊娠;克龄蒙组、空白对照组术后各2例再次妊娠。连续使用3个月达英-35,未出现明显严重不良反应。三组患者经流产后服务,术后自动采用有效避孕措施比率较术前均增加(P < 0.05)。【结论】 人工流产术后立即服用复方短效口服避孕药更合理、有益、安全。加强流产后服务对保护未婚女性生殖健康有意义。
【Objective】 To study the advantages and safety of the use of short-acting combined oral contraceptive (COC) post abortion in unmarried women. 【Methods】 A total of 110 cases of unmarried women who terminated the pregnant by artificial abortion, were randomly divided into Group A (taking Diane-35 after surgery, n = 43), Group B (taking Climen after surgery, n = 35), Group C (control group, n =32). Hormone drugs were administrated to patients in Group A and Group B immediately after induced abortion, Recommended even allowed to use three cycles. All patients in three groups were offered post abortion service. Bleeding time, time of menstruation turn over, menstrual disorder, the pregnancy, endometrial thickness and adverse drug reactions were observed and the patient compliance was evaluated. 【Results】 Group A Insist on taking 3 cycles of 25 cases,The time of bleeding and menstruation turn over in group A was less than group C (P < 0.05); the incidences of menstrual disorder in group A was lower than group B and group C (P < 0.05); Group B Insist on taking 3 cycles of 22 cases,There was no difference between group B and group C in the time of bleeding and menstruation turn over or the incidences of menstrual disorder(P > 0.05). No patient was pregnant in group A. Both group B and group C had 2 patients who were pregnant. No serious adverse drug reactions were observed after using Diane-35 for 3 months. After receiving the post abortion service, the rates of patients in three groups who taking effect contraceptive method post-operation were higher than pre-operation (P < 0.05). 【Conclusions】 Application of short-acting COC immediately after artificial abortion was reasonable, beneficial and safe. Strengthening post abortion service was of great significance in protecting unmarried women’s reproductive health.
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