【Objective】 To study the distribution characteristics of intrauterine lesions in the patients with assisted reproduction failure. 【Methods】 Clinical data of 256 infertility patients

who had the failure history of assisted reproduction (including IVF and artificial insemination) and took office hysteroscopy examinations in the First Affiliated Hospital of Sun Yat-sen University from January 2011 to July 2012

were retrospectively analyzed. 【Results】 In 256 assisted reproduction failure cases

the proportion of the patients with intrauterine lesions was 31.25% (80/256) and endometrial polyps (55%) was the main abnormalities of the intrauterine lesions

which had a higher incidence rate in the primary infertility group than the secondary infertility group (P = 0.011). The less often lesions of the uterus in the primary infertility group were endometrial local thickening and uterine malformation while intrauterine adhesions and thin endometrium in the secondary infertility group. Hysteroscopy’s relevance rate of polyps was 85%

which was much higher than that of transvaginal ultrasound (P < 0.00). The total clinical pregnancy rate in these 204 patients who had accepted the assisted reproduction treatment after the office hysteroscopy examinations was 35.29% (72/204). And the clinical pregnancy rate of the next assisted reproduction after taking office hysteroscopy examinations and treatment was higher in abnormal finding than normal finding (45.71% vs 29.85%

P = 0.024). 【Conclusion】 The most common intrauterine lesion in patients with the history of assisted reproduction failure was endometrial polyps

especially for the primary infertility patients. Besides we also need to pay attention to the thickness of endometria as well as the shape of uterine cavity. The office hysteroscopy examination has a high diagnostic rate of intrauterine lesions.