【Objective】 To evaluate the efficacy of treatment and investigate the prognostic factors of squamous cell carcinoma of the hard palate. 【Methods】 A total of 155 cases of squamous cell carcinoma of the hard palate hospitalized in Cancer Center

Sun Yat-sen University

from 1964 to 2008 were reviewed retrospectively. The cumulative survival rate was analyzed by Kaplan-Meier method. The factors were compared using the log-rank test. The influencing factors were screened by Cox proportional hazards model. 【Results】 The 5- and 10-year overall survival rates were 36.3% and 26.3%

respectively. The 5 years disease-specific survival rates for the patients treated with surgery or surgical comprehensive treatment group and non-operative treatment group were 44.7% and 24.3% (P = 0.002)

respectively. Multivariate analysis showed that margin positive and advanced stage were independently associated with decrease survival rates (P < 0.05). 【Conclusion】 Surgery or surgery dominated multi-modality therapy was the principal treatment modality for squamous cell carcinoma of the hard palate. Margin and clinical stage are independent factors affecting the prognosis.