【Objective】 The safety and efficacy of endoscopic ultrasonography (EUS) assistant elastic band or endoloop ligation methods

for the resection of upper gastrointestinal stromal tumor (GIST)

was evaluated. 【Methods】 The study included totally 58 patients with upper gastrointestinal stromal tumor which were determined by endoscopy and EUS. The standard procedure of endoscopic elastic band or endoloop ligation was performed for each of the patient. The entire patients received PPI treatment for 2 weeks and were followed up with endoscopy after 2 weeks. 【Results】 The lesion diameters of the 58 recruited patients were 0.5~4.0 cm (1.2±0.5)cm. They distribution in esophagus (44.8%)

stomach (39.7%) duodenal (15.5%) and located in muscularis propria (48.3%)

muscularis mucosae (41.4%)

submucosa (10.3%)

respectively; 53 (91.4%) out of them were sloughed completely. Four resulted in unsuccessful resection with the diameter larger than 1.5 cm (1.5~4.0 cm) and all located in muscularis propria

1(1.7%) quitted from the procedure because of intolerance. Statistics showed that the decisive factors for successful treatment were the sizes

layer of invasion and feature of growth. Transient bleeding occurred in 3 patients within 5 days after ligation and disappeared without special management. No perforation and other complications occurred. 【Conclusion】 Compared with conventional surgical operation

tumor size selective (<1.5 cm) EUS assistant endoscopic elastic band or endoloop ligation method is a safe

less suffering and less invasive method for the therapy of GIST in upper Gastrointestinal tract.